A new sesquiterpene, a new monoterpene and other constituents with anti-inflammatory activities from the roots of .

Nat Prod Res

Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji, P.R. China.

Published: February 2020

A new sesquiterpene () and a new monoterpene (), together with thirteen known compounds (-) were isolated from an ethanol extract of the roots of Sieb. et Zucc. The structures of compounds and were elucidated using HR-ESI-MS, 1D and 2D NMR spectroscopy. Anti-inflammatory effects of the isolated compounds were evaluated in terms of inhibition of nitric oxide, tumour-necrosis factor-α and interleukin-6 production in lipopolysaccharide-stimulated RAW264.7 cells. Compounds - and - significantly inhibited the levels of NO, TNF-α and IL-6 in LPS-induced RAW264.7 cells from concentrations of 3 μM to 30 μM.

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http://dx.doi.org/10.1080/14786419.2018.1532425DOI Listing

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