Double-Stranded RNA Sensing Determines Epithelial Cell Identity.

J Invest Dermatol

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Integrative Molecular and Biomedical Sciences Program, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address:

Published: January 2019

Skin epithelium is constituted by heterogeneous keratinocytes in different body areas. In this issue, Zhou et al. used transcriptome analysis to investigate the site-specific epidermal cell identity on volar skin. Keratin 9 is highly enriched in volar keratinocytes, and its expression is dependent on low expression of the double-stranded RNA receptor DDX58, suggesting that double-stranded RNA sensing could allow a potential approach to modulate skin thickness and durability.

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http://dx.doi.org/10.1016/j.jid.2018.08.008DOI Listing

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