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Immunohistochemical analysis of 147 cases of low-grade endometrial stromal sarcoma: refining the immunohistochemical profile of LG-ESS on a large, molecularly confirmed series.
Virchows Arch
January 2025
Department of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
Low-grade endometrial stromal sarcoma (LG-ESS) can present diagnostic challenges, due to its overlapping morphological features with other uterine mesenchymal tumors. Misdiagnosis rates remain significant, and immunohistochemical data for LG-ESS are limited to small series and inconsistent antibody panels. This study aimed to refine the IHC profile of LG-ESS by analyzing a large, molecularly confirmed series of 147 cases using a panel of 24 antibodies, including newer markers like transgelin and smoothelin.
View Article and Find Full Text PDFRisk factors for subclinical endometritis and its effect on reproductive performance in small-scale dairy farms.
Vet Anim Sci
March 2025
Doctorado en Ciencias Biológicas-Facultad de Ciencias Naturales-Universidad Autónoma de Querétaro. Av. de las Ciencias SN. Juriquilla. Santa Rosa Jáuregui, Querétaro, CP 76230, Mexico.
The study aimed to evaluate the effect of subclinical endometritis (SCE) on reproductive performance and identify risk factors for this pathology in small-scale dairies. In four small-scale dairies, 608 lactations were monitored for health issues, nutritional status, and reproductive events, and SCE was diagnosed based on endometrial polymorphonuclear counting (PMN%) at 30±5 (SCE30) and 60±5 (SCE60) days postpartum. The threshold for diagnosis was established according to the quartile distribution of PMN%; 4 % and 2 % for SCE30 and SCE60.
View Article and Find Full Text PDFResearch Status of Clustered Regulary Interspaced Short Palindromic Repeats Technology in the Treatment of Human Papillomavirus (HPV) Infection Related Diseases.
Cancer Control
January 2025
Department of Haide College, Ocean University of China, Qingdao, China.
CRISPR/Cas9 technology has rapidly advanced as a pivotal tool in cancer research, particularly in the precision targeting required for both detecting and treating malignancies. Its high specificity and low off-target effects make it exceptionally effective in applications involving Human Papillomavirus (HPV) related diseases, most notably cervical cancer. This approach offers a refined methodology for the rapid detection of viral infections and provides a robust platform for the safe and effective treatment of diseases associated with viral infections through gene therapy.
View Article and Find Full Text PDFButorphanol Tartrate Nasal Spray for Post-Cesarean Analgesia and Prolactin Secretion.
Med Sci Monit
January 2025
Department of Anesthesiology, The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
BACKGROUND Butorphanol, an opioid receptor agonist and antagonist, is widely used for post-cesarean section analgesia in the form of intravenous or intramuscular injection, but nasal sprays are less used. This study aimed to evaluate the analgesic effect of butorphanol nasal spray on uterine contraction pain after cesarean section and explore its effect on postpartum prolactin secretion. MATERIAL AND METHODS We randomly divided 120 patients scheduled for cesarean section into 3 groups (40 per group): intranasal saline (control), butorphanol intranasal (BI), and butorphanol pumped intravenously (BV).
View Article and Find Full Text PDFKey wound healing genes as diagnostic biomarkers and therapeutic targets in uterine corpus endometrial carcinoma: an integrated in silico and in vitro study.
Hereditas
January 2025
Department of Gynaecology and Obstetrics, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, Sichuan, China.
Background: Uterine Corpus Endometrial Carcinoma (UCEC) is a prevalent gynecologic malignancy with complex molecular underpinnings. This study identifies key woundhealing genes involved in UCEC and elucidates their roles through a comprehensive analysis.
Methods: In silico and in vitro experiments.
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