AI Article Synopsis
- BPA is an endocrine disrupting compound found in aquatic environments that affects lipid metabolism in fish, specifically in Gobiocypris rarus.
- In experiments, exposure to BPA for 3 and 6 weeks altered lipid content by affecting metabolism-related genes, particularly inhibiting fatty acid β-oxidation more than lipid synthesis.
- BPA also influenced the expression of specific genes (acaca, fasn, cpt1α) through changes in SREBP-1 binding, revealing a gender-specific effect on lipid metabolism in the fish.
Article Abstract
Bisphenol A (BPA), a representative endocrine disrupting compound, exists ubiquitously in the aquatic environment. Several studies on fish have validated the role of BPA in the lipid metabolism. However, the action mechanisms of BPA on lipid metabolism have been little studied. To clarify how BPA regulates lipid metabolism, Gobiocypris rarus were exposed to 15 μg/L BPA for 3 and 6 weeks. Results showed that BPA altered lipid content by regulating some metabolism-related genes. The BPA's inhibiting effect on fatty acid β-oxidation might be stronger than on lipid synthesis. BPA disturbed the expression of acaca (acetyl-CoA carboxylase), fasn (fatty acid synthase) and cpt1α (carnitine palmitoyltransferase 1α) by altering the sterol regulatory element binding protein 1 (SREBP-1) binding to their sterol regulatory elements (SREs). Our result also revealed that DNA methylation in the 5' flanking regions of cpt1α could perturb the SREBP-1 binding adjacent to its SRE in females under BPA exposure. Besides, BPA exposure led to gender-specific effect on fatty acid β-oxidation in G. rarus. This will contribute to our understanding of the regulation mechanisms of BPA on lipid metabolism in fish.
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| http://dx.doi.org/10.1016/j.aquatox.2018.12.011 | DOI Listing |
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