Few studies have examined individual differences in stress reactivity during pregnancy. The current study examined whether cortisol responses to a laboratory stressor (Trier Social Stress Test; TSST) significantly differed within an ethnically diverse sample of 34 pregnant women (38% Latina, 29% African American) identified to be at low (n = 17; i.e., low depressive symptoms) versus high risk for depression (n = 17; i.e., past history of depression and/or high depressive symptoms). Women at high depression risk, particularly those with a past history of depression, showed greater cortisol responses to the TSST than women at low depression risk, controlling for gestational age, parity, and education (p = 0.03). Moreover, African American women, particularly those at high depression risk, showed blunted cortisol responses to the TSST compared to non-African American women (p = 0.02). Our results highlight risk factors for depression during pregnancy and have strong implications for reducing health disparities in this population.
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http://dx.doi.org/10.1016/j.biopsycho.2018.12.005 | DOI Listing |
JCEM Case Rep
February 2025
Clinica Medica 3, Department of Medicine-DIMED, University Hospital of Padova, Padova 35128, Italy.
Growth hormone (GH) secretion by the pituitary is regulated by stimulatory and inhibitory pathways such as growth hormone releasing hormone (GHRH) and somatostatin, respectively, being also modulated by different neurotransmitters acting at the hypothalamic/pituitary level. The pineal gland hormone melatonin regulates GH secretion in many mammals, including humans, although its role in modulating GH secretion has been debated. We describe the case of a young woman chronically taking melatonin for sleep disturbances, referring to her general practitioner for flushing that appeared just after starting melatonin intake.
View Article and Find Full Text PDFChild Maltreat
January 2025
Mt. Hope Family Center, University of Rochester, Rochester, NY, USA.
Identifying proximal and multigenerational distal risk mechanisms through which adversity exposure may shape neuroendocrine dysregulation among children is critical to advancing effective preventive interventions for adversity-exposed individuals. Utilizing longitudinal data ( = 247), the current study examined maternal and offspring history of childhood maltreatment (CM) as predictors of offspring cortisol/DHEA ratios, and, in exploratory analyses, extended this longitudinally to offspring depressive symptoms in young adulthood. Youth (ages 8-13 years) initially attended a research camp, then were followed up approximately eight years later (ages 18-22 years).
View Article and Find Full Text PDFJ Glaucoma
January 2025
Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Prcis: Cognitive impairment in multiple domains was observed in primary open angle glaucoma patients as compared to age and gender matched healthy controls.
Objective: Evaluation of cognitive impairment in individuals with Primary Open Angle Glaucoma (POAG).
Methods: In this case-control study, individuals with POAG (cases, n=70) were compared with age- and sex-matched healthy individuals (controls, n=70) using detailed ophthalmological evaluation, cognitive assessment and serum cortisol level.
J Dent Sci
January 2025
Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background/purpose: Discoid lupus erythematosus (DLE) serves as an interdisciplinary disease involved in dermatology and stomatology in many cases. The purpose of this study was to analyze the scientometric characteristics and research trends of DLE.
Materials And Methods: All the papers on DLE were comprehensively retrieved from the Scopus database.
World J Gastrointest Surg
January 2025
Department of Gastrointestinal Surgery, Nanhua Hospital Affiliated to University of South China, Hengyang 421002, Hunan Province, China.
Background: With the continuous development of laparoscopic techniques in recent years, laparoscopic total mesorectal excision (LapTME) and laparoscopic-assisted transanal total mesorectal excision (TaTME) have gradually become important surgical techniques for treating low-lying rectal cancer (LRC). However, there is still controversy over the efficacy and safety of these two surgical modalities in LRC treatment.
Aim: To compare the efficacy of LapTME TaTME in patients with LRC.
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