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Prevalence of Immature Survival Data for Anti-Cancer Drugs Presented to the National Institute for Health and Care Excellence between 2018-2022.
Value Health
December 2024
Sheffield Centre for Health and Related Research, University of Sheffield, Regent Court, 30 Regent Street, Sheffield, S1 4DA; Delta Hat Limited, Nottingham, UK.
Objectives: Between 2015 and 2017, 41% of NICE cancer single technology appraisal (STA) decisions relied upon immature survival data. This occurs when clinical trials that form the evidence base in support of new or existing technologies suffer from limited follow-up. During this period, NICE did not negatively recommend any cancer technologies that used immature data.
View Article and Find Full Text PDFSpecialist clinical pathways in audiology services for adults living with coexisting hearing loss and dementia: a scoping review protocol.
BMJ Open
December 2024
Hearing Sciences, Mental Health and Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, UK
Introduction: Both hearing loss and dementia are associated with ageing, and it is thought that many individuals living with dementia also live with hearing loss. Despite the large comorbidity between these two disorders, there remains a clear lack of established guidelines in audiological services for assessing and managing patients living with dementia. This scoping review aims to examine whether specialist clinical pathways exist in audiology services for people living with coexisting hearing loss and dementia and to describe the specific components and features of these pathways.
View Article and Find Full Text PDFExtensive research has shown that spending time in natural greenspaces has a positive impact on health. However, there is limited evidence regarding potential factors that may influence these effects. This review aimed to assess the strength of the evidence and potential impact of exposure to green and bluespaces on dietary outcomes in adults.
View Article and Find Full Text PDFUpdates in innovation of the treatment of pyoderma gangrenosum.
Expert Rev Clin Pharmacol
December 2024
Department of Dermatology, Oregon Health and Science University, Portland, OR, USA.
Introduction: Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis characterized by rapidly enlarging, painful ulcers with undermined borders. The management of PG is challenging due to the lack of standardized evidence-based treatments.
Areas Covered: This review examines recent efforts to establish standardized outcomes for clinical trials to facilitate the drug development process for PG.
An updated systematic review and meta-analysis exploring the efficacy and safety of dimethyl fumarate (DMF) for patients with multiple sclerosis (MS).
BMJ Neurol Open
December 2024
Ain Shams University, Faculty of Medicine, Cairo, Egypt.
Background: Dimethyl fumarate (DMF) is increasingly used in treating multiple sclerosis (MS) with controversial results of the safety and efficacy of different DMF doses. We aimed to systematically review the literature to examine the safety and efficacy of DMF for MS patients.
Methods: We searched PubMed Medline, Cochrane, Web of Science, Scopus databases and clinicaltrials.
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