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Profile of haemostasis and coagulation in patients with peritoneal carcinomatosis undergoing cytoreductive surgery with hyperthermal chemotherapy.
Eur J Surg Oncol
December 2024
Critical Care Division, University Hospital 'Virgen Del Rocío', Avda Manuel Siurot S/n, 41013, Seville, Spain. Electronic address:
Background: One-third of patients with peritoneal carcinomatosis undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) present alterations in conventional coagulation test results. However, perioperative coagulation has not been systematically investigated in these patients. This study aimed to investigate hemostatic changes in such patients.
View Article and Find Full Text PDFUnderstanding the development of tuberculous granulomas: insights into host protection and pathogenesis, a review in humans and animals.
Front Immunol
December 2024
Department of Academic Affairs, National Jewish Health, Denver, CO, United States.
Granulomas, organized aggregates of immune cells which form in response to (), are characteristic but not exclusive of tuberculosis (TB). Despite existing investigations on TB granulomas, the determinants that differentiate host-protective granulomas from granulomas that contribute to TB pathogenesis are often disputed. Thus, the goal of this narrative review is to help clarify the existing literature on such determinants.
View Article and Find Full Text PDFFactor XIII-A transglutaminase contributes to Neutrophil Extracellular Trap (NET)-mediated fibrin network formation and crosslinking.
Thromb Haemost
December 2024
Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, Canada.
Background: Neutrophil Extracellular Traps can contribute to thrombosis via stabilization fibrin network, which is normally conducted by plasma transglutaminase, Factor XIII-A as part of coagulation cascade. The possible presence and activity of FXIII-A in neutrophils or during NETosis is unknown. Here, we investigated potential presence of FXIII-A in neutrophils and participation in NET-fibrinogen interaction.
View Article and Find Full Text PDFInfluence of rainfall on physicochemical characteristics of runoff water and sediments in riverbeds affected by mining and agricultural activities.
Sci Total Environ
December 2024
Sustainable Use, Management and Reclamation of Soil and Water Research Group, Universidad Politécnica de Cartagena, Paseo Alfonso XIII 48, 30203 Cartagena, Spain.
Article Synopsis
- The Cartagena-La Union mining district in SE Spain faces environmental issues due to mining waste and agricultural runoff, affecting the Mar Menor lagoon.
- This study analyzed sediment and runoff water properties in two dry riverbeds before and after a rainy period, focusing on pollution levels for nutrients and heavy metals.
- Results indicated high nitrate concentrations in the runoff water from El Albujón, while La Carrasquilla showed consistent metal contamination in sediments, exceeding WHO standards during the rainy events.
A Rare Case of Congenital Factor XIII Deficiency Secondary to Hyperconsumption: A Case Report.
Cureus
November 2024
General Medicine, Saveetha Medical College, Chennai, IND.
Acquired Factor XIII (FXIII) deficiency is a rare condition often associated with underlying medical conditions or medications. We present a case of a 23-year-old male, who presented with prolonged bleeding from a traumatic ulcer site on his left leg. Initial laboratory investigations revealed a severe deficiency in FXIII activity (30%) and antigen levels (25%), with no evidence of congenital disorders or other underlying pathologies.
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