Oxidative stress and increased production of reactive oxygen species have been implicated in pesticides and heavy metals toxicity. The objective of this study was to investigate the efficacy of Turnera diffusa Willd (damiana) on counteracting fenitrothion (FNT) and/or potassium dichromate (CrVI)-induced testicular toxicity and oxidative injury in rats. FNT and/or CrVI intoxicated animals revealed a significant increase in thiobarbituric acid reactive substances and hydrogen peroxide levels. While, reduced glutathione and protein content, as well as antioxidant enzymes, phosphatases, and aminotransferases activities, were significantly decreased. In addition, significant changes in testosterone and follicle-stimulating hormone levels were detected. Furthermore, histological and immunohistochemical alterations were observed in rat testes and this supported the observed biochemical changes. On the other hand, rats treated with damiana alone decreased lipid peroxidation and increased most of the examined parameters. Moreover, damiana pretreatment to FNT and/or CrVI-intoxicated rats showed significant improvement in lipid peroxidation, enzyme activities, and hormones as compared with their respective treated groups. Conclusively, rats treated with both FNT and/or CrVI showed pronounced hazardous effect especially in their combination group in addition, Turnera diffusa had a potential protective role against FNT and/or CrVI induced testicular toxicity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/tox.22688 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Visible Light-Driven Direct Z-Scheme HoSmSbO/YbDyBiNbO Heterojunction Photocatalyst for Efficient Degradation of Fenitrothion.
Molecules
December 2024
School of Physics, Changchun Normal University, Changchun 130032, China.
A highly versatile Z-scheme heterostructure, HoSmSbO/YbDyBiNbO (HYO), was synthesized using an ultrasonic-assisted solvent thermal method. The HYO heterojunction, composed of dual ABO compounds, exhibits superior separation of photogenerated carriers due to its efficient Z-scheme mechanism. The synergistic properties of HoSmSbO and YbDyBiNbO, particularly the excellent visible light absorption, enable HYO to achieve exceptional photocatalytic performance in the degradation of fenitrothion (FNT).
View Article and Find Full Text PDFFluorescence sensor based on Methionine-Modified silver nanoparticles located on Fe-BTC metal-organic framework (Meth-AgNPs@Fe-BTC) for trace detection of fenitrothion pesticide in aqueous samples.
Spectrochim Acta A Mol Biomol Spectrosc
March 2025
Department of Chemistry, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran; Department of Chemistry, Jundi-Shapur University of Technology, Dezful, Iran.
This research introduces a new "turn-on mode" fluorescence sensor for the detection of fenitrothion (FNT) pesticide in various samples. The sensor is constructed using a porous metal-organic framework (Fe-BTC) as a template to locate silver nanoparticles (AgNPs) and methionine amino acid (Meth). Methionine acts as a bridge, facilitating the interaction between FNT and AgNPs, which subsequently results in the release of AgNPs from the composite structure.
View Article and Find Full Text PDFAdequacy of Anesthesia Guidance for Combined General/Epidural Anesthesia in Patients Undergoing Open Abdominal Infrarenal Aortic Aneurysm Repair; Preliminary Report on Hemodynamic Stability and Pain Perception.
Pharmaceuticals (Basel)
November 2024
Collegium Medicum, WSB University, 41-300 Dabrowa Gornicza, Poland.
Article Synopsis
- Hemodynamic instability and inappropriate postoperative pain perception (IPPP) pose significant challenges in managing patients undergoing elective open lumbar aortic aneurysm repair under general anesthesia, with inadequate opioid use risking adverse events.
- In a study involving 75 patients, three types of postoperative analgesia were tested: thoracic epidural anesthesia with ropivacaine, thoracic epidural with bupivacaine, and intravenous metamizole/tramadol, with the impact on pain levels and hemodynamic stability measured.
- Results showed that nearly half of the patients still experienced IPPP despite preventive measures, and while no acute pain was reported in the ropivacaine group, this was associated with noticeable hemodynamic instability; however
Bioavailability enhancement of formononetin by incorporation of natural bioenhancer in phospholipid complex.
Pharm Dev Technol
December 2024
Pharmaceutics and Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow, India.
Formononetin (FNT) has limited application due to poor water solubility and substantial phase II metabolism. In the present study, we used phospholipid complex (PC) containing FNT and UDP-glucuronosyltransferase (UGT1A1) inhibitor piperine (PIP) to overcome FNT limitations. We characterized and compared both FNT-PC and FNT-PIP-PC complexes.
View Article and Find Full Text PDFEnhanced Understanding of Facial Nerve Anatomy and Arborization in the Indian Population: Implications for Surgical Procedures.
Facial Plast Surg
October 2024
Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherry, India.
The anatomy and arborization patterns of the extraparotid facial nerve show considerable variation among different populations, impacting surgical approaches in plastic, head and neck, and ENT surgeries. This study focuses on the Indian population to provide a detailed understanding of these variations, specifically highlighting the Davis type IV arborization pattern's prevalence and its clinical relevance. We conducted a comprehensive dissection of 16 formalin-preserved Indian cadaveric hemifaces.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!