Introduction: The Asia-Pacific Clinical Guidelines for the Management of Frailty recommended the use of validated measurement tools for identifying frailty. In an effort to contribute to the development of best practice guidelines in frailty identification and measurement, our scoping review aimed to present a summary of published research on this topic among older adults in Singapore. Our findings are important given the need to consider the context of use and the goals of measurement in using validation tools.
Materials And Methods: We searched PubMed and CINAHL® for articles describing the identification and measurement of frailty among older adults (≥60 years) in Singapore and mined the bibliographies of eligible articles. An article was eligible if it involved empirical research on frailty using a structured frailty definition. We described such articles and the conceptual definitions they used, and summarized their operationalization of frailty.
Results: Our search yielded 165 records. After 2-stage screening of titles/abstracts and full-text articles, we retained 32 eligible articles for data extraction and thematic analysis. The extant literature in Singapore includes observational cross-sectional and longitudinal studies and intervention studies across community and tertiary care settings. Eligible articles commonly used the frailty phenotype and the deficit accumulation models in defining frailty, and reported measuring components of physical, cognitive, and/or social frailty.
Conclusion: Our scoping review provided a broad evidence synthesis of the underpinnings of research on frailty identification and measurement in Singapore. Consistently applying standard methods and approaches in frailty identification and measurement can support evidence-based practice and policies in Singapore.
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Alzheimers Dement
December 2024
ADEL Institute of Science & Technology (AIST), ADEL, Inc., Seoul, Korea, Republic of (South).
Background: Abnormal aggregation and accumulation of tau is a hallmark of tauopathy including Alzheimer's disease. Effective targeting of tau for therapeutic purposes requires a clear understanding of its epitope landscape with identification of a key pathogenic tau species. Despite numerous proposed and tested tau epitopes, ranging from the N-terminus to the microtubule-binding region and C-terminus, the most effective target remains elusive.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Relecura, Bangalore, karnataka, India.
Background: Clinical Dementia Rating (CDR) and its evaluation have been important nowadays as its prevalence in older ages after 60 years. Early identification of dementia can help the world to take preventive measures as most of them are treatable. The cellular Automata (CA) framework is a powerful tool in analyzing brain dynamics and modeling the prognosis of Alzheimer's disease.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Minnesota, Minneapolis, MN, USA.
Background: Across a broad range of physical and cognitive outcomes in gerontology and geriatric practice, it is fundamentally important to establish systems for clinical decision-making. Current technological solutions include sensors for monitoring movement activity, however many of these methods are complex, invasive, and dependent on factors such as compliance, context, and idyllic conditions. An alternative approach to monitoring is through continuously active, noninvasive radiofrequency (NRF) sensors.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
UsAgainstAlzheimer's, Washington, DC, USA.
Background: Previous What Matters Most (WMM) research identified and verified patient-important concepts among a diverse population of people living with Alzheimer's disease (PLWAD) and their care partners across all stages of Alzheimer's disease (AD). Additionally, a conceptual model of disease was developed using hypothesized domains and was further refined using qualitative data (Figure 1). This next phase of WMM research aims to quantify the importance of concepts, impacts, and outcomes and to determine priorities among PLWAD and care partners within a diverse sample including underrepresented ethnic and racial groups at each level of disease severity.
View Article and Find Full Text PDFThe use of parent-report screeners for early detection of autism is time- and cost-efficient in clinical settings but their utility may vary by respondent characteristics. This study aimed to examine the degree to which infants' age and sex impacted parental reports of early behavioral signs of autism captured by the First Years Inventory Version 3.1 (FYIv3.
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