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[Integration of Inventory Data from Cohort and Registry Studies into an Existing Research Network: National Pandemic Cohort Network (NAPKON)].
Gesundheitswesen
October 2024
Universitätsklinikum Würzburg, Institut für medizinische Datenwissenschaften, Würzburg, Germany.
In the early phase of the COVID-19 pandemic, many local collections of clinical data on patients infected with SARS-CoV-2 were initiated in Germany. As part of the National Pandemic Cohort Network (NAPKON) of the University Medicine Network, the "Integration Core" was established to design the legal, technical and organisational requirements for the integration of inventory data into ongoing prospective data collections and to test the feasibility of the newly developed solutions using use cases (UCs). Detailed study documents of the data collections were obtained.
View Article and Find Full Text PDFCLEAR - clozapine in early psychosis: study protocol for a multi-centre, randomised controlled trial of clozapine vs other antipsychotics for young people with treatment resistant schizophrenia in real world settings.
BMC Psychiatry
February 2024
Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Background: Clozapine is an antipsychotic drug with unique efficacy, and it is the only recommended treatment for treatment-resistant schizophrenia (TRS: failure to respond to at least two different antipsychotics). However, clozapine is also associated with a range of adverse effects which restrict its use, including blood dyscrasias, for which haematological monitoring is required. As treatment resistance is recognised earlier in the illness, the question of whether clozapine should be prescribed in children and young people is increasingly important.
View Article and Find Full Text PDFCharacterization of variant reclassification and patient re-contact in a cancer genetics clinic.
J Genet Couns
December 2022
Karmanos Cancer Institute, Detroit, Michigan, USA.
Expanded genetic testing guidelines for hereditary cancers, increased utilization of large multigene panels, and improved methods for reclassifying variants have led to a greater need to understand how variant reclassification and patient re-contact are managed. This study aimed to describe the process of variant reclassification and subsequent patient re-contact at a comprehensive cancer genetic counseling service in a large metropolitan medical center with several statewide satellite locations. A retrospective chart review was performed to identify reclassified variants between 1/1/1997 and 12/1/2020.
View Article and Find Full Text PDFA Cross-Sectional, Questionnaire-Based Study on Drug Treatment Awareness in Schizophrenia Patients and Caregivers: An Unexplored Avenue.
Indian J Psychol Med
March 2022
Dept. of Psychiatry, Seth G.S. Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, India.
Background: Schizophrenia is associated with high relapse rates, and medication nonadherence is a major factor contributing toward relapse. Since medication adherence and treatment awareness are linked, an alarming need was felt to evaluate the level of drug treatment awareness in patients who have schizophrenia. Besides, patients who have schizophrenia are often dependent on their caregivers for medications.
View Article and Find Full Text PDFExploring the impact of experiencing a long lie fall on physical and clinical outcomes in older people requiring an ambulance: A systematic review.
Int Emerg Nurs
May 2022
School of Human and Health Sciences, University of Huddersfield, Huddersfield, UK. Electronic address:
Background: The long term impacts of experiencing a 'long lie' following a fall in the older person are poorly understood. This systematic review explored the impact of a long lie fall on physical and clinical outcomes in older people requiring an ambulance.
Methods: PRISMA guidelines were followed.
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