Background: Oropharyngeal Cancers (OC) is a commonly-seen disease with a high risk. The earlier studies of miRNAs on this disease were restricted by factors as sequencing platform, filtration conditions, causing the inconformity in the obtained result. We aimed to explore the miRNA biomarkers that can function as the predictive and therapeutic markers. Meta-analysis was performed on the currently obtained miRNA result and the functions of the target genes regulated by meta-signature miRNA were further investigated.
Material And Methods: Seven representative miRNA datasets of OC were selected, and the meta-signature miRNAs were determined by overlap comparison. The corresponding target genes were predicted by TargetScan software. Then, functional enrichment and transcriptional factors analysis were performed on these target genes by DAVID (The Database for Annotation, Visualization, and Integrated Discovery) dataset and Tfacts dataset.
Results: Eight meta-signature miRNAs were identified, including seven were up-regulated and one down-regulated (hsa-miR-203a-5p). The up-regulated miRNAs were mainly enriched in pathways as GO:0000122-negative regulation of transcription from RNA polymerase II promoter, phosphatidylinositol phosphorylation, MAPK signaling pathway, and Ras signaling pathway, etc., while the down-regulated miRNAs were enriched in pathways as, response to reactive oxygen species, p53 signaling pathway, calcium signaling pathway, etc. A total of 124 transcription factors (TFs) were identified, 43 among were found to co-exist in both types of target genes.
Conclusion: Eight important miRNAs were identified by meta-analysis as well as the corresponding target genes and transcription factors. The potential functions were revealed, which will provide novel insights for the target treatment of OC.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cancergen.2018.10.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Coixol-Loaded Hydrogels Promote Osteochondral Defect Repair via Modulation of Ferroptosis and Autophagy in Chondrocytes.
ACS Biomater Sci Eng
January 2025
The Affiliated Ganzhou Hospital of Nanchang University, Meiguan Avenue No. 16, Ganzhou 341000, China.
Osteoarthritis (OA) is a chronic multifactorial disease characterized by cartilage degeneration, pain, and reduced mobility. Current therapies primarily aim to relieve pain and restore function, but they often have limited effectiveness and side effects. Coixol, a bioactive compound from Coix lacryma-jobi L.
View Article and Find Full Text PDFA critical view of silk fibroin for non-viral gene therapy.
Int J Biol Macromol
January 2025
National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, No. 199 Ren'ai Road, Industrial Park, Suzhou 215123, PR China. Electronic address:
Exogenous genes are inserted into target cells during gene therapy in order to compensate or rectify disorders brought on by faulty or aberrant genes. However, gene therapy is still in its early stages because of its unsatisfactory therapeutic effects which are mainly due to low transfection efficiency of vectors, high toxicity, and poor target specificity. A natural polymer with numerous bioactive sites, good mechanical qualities, biodegradability, biocompatibility, and processability called silk fibroin has gained attention as a possible gene therapy vector.
View Article and Find Full Text PDFAP2M1 as the potential biomarker for prediction of the response of atopic dermatitis to Dupilumab therapy: Multi-omics analysis and evidence.
Int J Biol Macromol
January 2025
Department of Dermatology, the Affiliated Hospital of Guilin Medical University, Guilin Medical University, Guilin, China. Electronic address:
Many atopic dermatitis (AD) patients have suboptimal responses to Dupilumab therapy. This study identified key genes linked to this resistance using multi-omics approaches to benefit more patients. We selected a prospective cohort of 54 CE treated with Dupilumab from the GEO database.
View Article and Find Full Text PDFThe pivotal role of CRIHSP sequences in orchestrating antigen receptor diversity and genomic stability within antigen receptor germline genes.
Int J Biol Macromol
January 2025
Henan Province Engineering Research Center of Innovation for Synthetic Biology, School of Life Sciences and Technology, Xinxiang Medical University, Xinxiang, 453003, Henan, China; School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, 453003, Henan, China. Electronic address:
The mechanisms underlying antigen receptor germline gene diversification have always been a topic of intensive study. Here, we discovered that the frequency of stem-loop sequences in the antigen receptor germline gene region is remarkably higher than the genomic background. By analyzing these stem-loop sequences' similarity and distribution patterns, we found that clustered regularly interspaced homologous stem-loop pairs (CRIHSP) are widely present on the germline genes of antigen receptors in different species.
View Article and Find Full Text PDFCDK1 inhibitor RO-3306 enhances BTKi potency in diffuse large B-cell lymphoma by suppressing JAK2/STAT3 signaling.
Int J Biol Macromol
January 2025
Department of Hematology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian 223300, Jiangsu Province, PR China; Key Laboratory of Hematology of Nanjing Medical University, Nanjing 210029, Jiangsu Province, PR China. Electronic address:
Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma in adults, which characterized by a high degree of heterogeneity in terms of clinical presentation, molecular phenotype, and genetic features. However, approximately 30 %-40 % of patients are refractory to standard chemotherapy, and their prognosis is poor. The emergence of small-molecule inhibitors, such as Bruton's tyrosine kinase inhibitors (BTKi), has greatly improved the treatment of DLBCL; however, drug resistance associated with small-molecule inhibitors has greatly limited their clinical application.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!