Targeting Mammalian Translational Inhibition with Tetracyclines.

Cell Chem Biol

Chemical Biology Laboratory, National Cancer Institute, Frederick MD, 21702, USA. Electronic address:

Published: December 2018

In this issue of Cell Chemical Biology, Mortison et al. (2018) report an in-depth mechanistic study of targets of two different tetracyclines in mammalian cells. Unbiased chemoproteomics and RNA sequence mapping help identify specific ribosomal substructures bound by tetracyclines, providing insight into the therapeutic potential for tetracyclines in many diseases.

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http://dx.doi.org/10.1016/j.chembiol.2018.12.006DOI Listing

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