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Article Abstract
A useful catalytic enantioselective approach has been developed for the synthesis of chiral ketamine analogs using Rh(II)-catalyzed amination of triisopropylsilyl enol ethers to form α-amino ketones with O-(4-nitrophenyl)hydroxylamine as nitrogen donor in 81-91% ee.
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| http://dx.doi.org/10.1021/acs.orglett.8b03733 | DOI Listing |
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