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Oxygen-dependent proteolysis regulates the stability of angiosperm polycomb repressive complex 2 subunit VERNALIZATION 2. | LitMetric

AI Article Synopsis

  • The study explores how the polycomb repressive complex 2 (PRC2) regulates gene repression in flowering plants and identifies a new mechanism for its control related to oxygen levels.
  • Researchers discovered that the plant PRC2 subunit VRN2 has an N-terminal degron that triggers its degradation, shaped by early angiosperm evolution through gene duplication.
  • The findings suggest that environmental factors like hypoxia and cold exposure increase VRN2 levels by interfering with its degradation, potentially linking environmental signals to the epigenetic regulation of plant growth and development.

Article Abstract

The polycomb repressive complex 2 (PRC2) regulates epigenetic gene repression in eukaryotes. Mechanisms controlling its developmental specificity and signal-responsiveness are poorly understood. Here, we identify an oxygen-sensitive N-terminal (N-) degron in the plant PRC2 subunit VERNALIZATION(VRN) 2, a homolog of animal Su(z)12, that promotes its degradation via the N-end rule pathway. We provide evidence that this N-degron arose early during angiosperm evolution via gene duplication and N-terminal truncation, facilitating expansion of PRC2 function in flowering plants. We show that proteolysis via the N-end rule pathway prevents ectopic VRN2 accumulation, and that hypoxia and long-term cold exposure lead to increased VRN2 abundance, which we propose may be due to inhibition of VRN2 turnover via its N-degron. Furthermore, we identify an overlap in the transcriptional responses to hypoxia and prolonged cold, and show that VRN2 promotes tolerance to hypoxia. Our work reveals a mechanism for post-translational regulation of VRN2 stability that could potentially link environmental inputs to the epigenetic control of plant development.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303374PMC
http://dx.doi.org/10.1038/s41467-018-07875-7DOI Listing

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