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Preclinical characterization of MTX-101: a novel bispecific CD8 Treg modulator that restores CD8 Treg functions to suppress pathogenic T cells in autoimmune diseases.
Front Immunol
November 2024
Mozart Therapeutics, Seattle, WA, United States.
Article Synopsis
- - Regulatory CD8 T cells (CD8 Treg) usually help control harmful CD4 T cells, but in autoimmune diseases, they often fail, partly due to inhibitory receptors that limit their activation.
- - A new bispecific antibody called MTX-101 targets these inhibitory receptors and CD8 T cells to enhance the ability of CD8 Treg to eliminate pathogenic CD4 T cells in various experimental models.
- - In studies, MTX-101 improved CD8 Treg activity, reduced harmful CD4 T cell expansion, and protected tissues from damage without triggering excessive inflammation, showing promise for treating autoimmune disorders.
Acute effects of Mozart K.448 on interictal epileptiform discharges in adult patients with drug-resistant focal epilepsy: A crossover randomized controlled trial.
Seizure
December 2024
Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Chulalongkorn Comprehensive Epilepsy Center of Excellence (CCEC), King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, Thailand. Electronic address:
Article Synopsis
- This study investigated if listening to Mozart K.448 could reduce interictal epileptiform discharges (IEDs) in adults with drug-resistant focal epilepsy.
- It used a crossover randomized controlled trial design with 26 participants, who were divided into two groups: one listening to Mozart and the other in silence.
- Results showed that 61.5% of patients listening to Mozart had significant IED reduction, and the Mozart group had fewer IEDs compared to the control group, suggesting that the music may help manage epilepsy symptoms, especially in patients with temporal lobe epilepsy.
Effects of Mozart-Orff parent-child music therapy among mothers and their preschool children with autism spectrum disorder: A mixed-methods randomised controlled trial.
BMC Pediatr
October 2024
Department of Child Health Care, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.
Background: Autism spectrum disorder (ASD) negatively impacts mental health, particularly in mothers of autistic children who experience heightened stress. Applied behaviour analysis (ABA) and music therapy are recognised interventions for improving ASD symptoms. However, the specific benefits of parent-child music therapy and ABA for autistic children and their mothers remain uncertain.
View Article and Find Full Text PDFApplication of Mozart's Sonata for Two Pianos in D Major in Children with Epilepsy and Effect of Acoustic Quality on Epileptic Discharges.
Noise Health
September 2024
Department of Pediatrics, the Affiliated Hospital (Group) of Putian University, Putian, Fujian, 351100, China.
Background: Mozart's Sonata for Two Pianos in D Major (K448) is a classic double piano work. This study investigated its effect on children with epilepsy (EP) and analyzed the changes in electroencephalography (EEG) among children on the basis of acoustic quality.
Methods: The clinical data of 150 children with EP in the Affiliated Hospital (Group) of Putian University from March 2020 to March 2023 were retrospectively analyzed.
Comparative analysis of noise and music exposure on inflammatory responses on lipopolysaccharide-induced septic rats.
Hum Exp Toxicol
September 2024
Department of Emergency and Critical Care Center, Renmin Hospital, Hubei University of Medicine, Hubei, China.
Objective: Environmental factors such as noise and music can significantly impact physiological responses, including inflammation. This study explored how environmental factors like noise and music affect lipopolysaccharide (LPS)-induced inflammation, with a focus on systemic and organ-specific responses.
Materials And Methods: 24 Wistar rats were divided into four groups ( = 6 per group): Control group, LPS group, noise-exposed group, and music-exposed group.
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