AI Article Synopsis

  • - The study investigates the link between vitamin intake and amyloid-β peptide (Aβ) deposition in patients with cognitive impairments, focusing on 49 participants divided into two groups: those with subjective cognitive impairment and those with mild cognitive impairment.
  • - Researchers discovered that higher intakes of specific vitamins, particularly pantothenic acid, were associated with a greater cerebral Aβ burden, suggesting that diets rich in certain vitamins may influence the progression of Alzheimer's disease.
  • - The results highlight the potential role of pantothenic acid in Alzheimer's disease, offering insights into dietary strategies that could help in preventing or managing the condition.

Article Abstract

Alzheimer's disease (AD) is a neurodegenerative disease characterized by the deposition of amyloid-β peptide (Aβ) in diffuse and neuritic plaques. Previous research has suggested that certain vitamins may prevent this process. In the present study, we evaluated the relationship between vitamin intake and cerebral Aβ burden in patients with cognitive impairment. This study included 19 patients with subjective cognitive impairment and 30 patients with mild cognitive impairment. All patients underwent brain MRI and F-florbetaben positron emission tomography. The Food Frequency Questionnaire was used to evaluate dietary intake of the 15 vitamins. Intake of vitamin B6 ( = 0.027), vitamin K ( = 0.042), vitamin A ( = 0.063), riboflavin ( = 0.063), β-carotene ( = 0.081), pantothenic acid ( = 0.092), and niacin ( = 0.097) was higher in the Aβ-positive group than in the Aβ-negative group. Multivariate linear regression analysis revealed that pantothenic acid intake was an independent determinant of cerebral Aβ burden (β = 0.287, = 0.029). No significant correlations were observed between cerebral Aβ burden and the intake of other vitamins. Our findings demonstrated that pantothenic acid intake may be associated with increased cerebral Aβ burden in patients with cognitive impairment. These results may offer insight into potential strategies for AD prevention.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294831PMC
http://dx.doi.org/10.29219/fnr.v62.1415DOI Listing

Publication Analysis

Top Keywords

cognitive impairment
20
pantothenic acid
16
cerebral aβ
16
aβ burden
16
burden patients
12
patients cognitive
12
dietary intake
8
impairment patients
8
intake vitamins
8
acid intake
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!