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A microRNA cluster in the Fragile-X region expressed during spermatogenesis targets FMR1. | LitMetric
Testis-expressed X-linked genes typically evolve rapidly. Here, we report on a testis-expressed X-linked microRNA (miRNA) cluster that despite rapid alterations in sequence has retained its position in the Fragile-X region of the X chromosome in placental mammals. Surprisingly, the miRNAs encoded by this cluster () have a predilection for targeting the immediately adjacent gene, , an unexpected finding given that miRNAs usually act , not Robust repression of is conferred by combinations of miRNAs induced in Sertoli cells (SCs) during postnatal development when they terminate proliferation. Physiological significance is suggested by the finding that FMRP, the protein product of , is downregulated when miRNAs are induced, and that FMRP loss causes SC hyperproliferation and spermatogenic defects. miRNAs not only regulate the expression of FMRP, but also regulate the expression of eIF4E and CYFIP1, which together with FMRP form a translational regulatory complex. Our results support a model in which family members act cooperatively to regulate the translation of batteries of mRNAs in a developmentally regulated manner in SCs.
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