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Hydrogel Coating Optimization to Augment Engineered Soft Tissue Mechanics in Tissue-Engineered Blood Vessels.
Bioengineering (Basel)
June 2023
Department of Biomedical Engineering, Wayne State University, Detroit, MI 48201, USA.
Tissue engineering has the advantage of replicating soft tissue mechanics to better simulate and integrate into native soft tissue. However, soft tissue engineering has been fraught with issues of insufficient tissue strength to withstand physiological mechanical requirements. This factor is due to the lack of strength inherent in cell-only constructs and in the biomaterials used for soft tissue engineering and limited extracellular matrix (ECM) production possible in cell culture.
View Article and Find Full Text PDFNanostructured fibrin-based hydrogel membranes for use as an augmentation strategy in Achilles tendon surgical repair in rats.
Eur Cell Mater
April 2022
Departamento de Histología, Facultad de Medicina, Universidad de Granada, Av. de la Investigación 11 Torre A, 5a Planta, Granada, 18016
Hydrogels are polymeric biomaterials characterised by their promising biological and biomechanical properties, which make them potential alternatives for use in tendon repair. The aim of the present study was to generate in vitro, and determine the therapeutic efficacy in vivo, of novel nanostructured fibrin-based hydrogels to be used as an augmentation strategy for the surgical repair of rat Achilles tendon injuries. Fibrin, fibrin-agarose and fibrin-collagen nanostructured hydrogels (NFH, NFAH and NFCH, respectively) were generated and their biomechanical properties and cell-biomaterial interactions characterised ex vivo.
View Article and Find Full Text PDFHemostatic materials in wound care.
Burns Trauma
September 2021
Department of Biosystems Engineering, University of Manitoba, 75A Chancellor's Circle, Winnipeg, MB, R3T 2N2 Canada.
Blood plays an essential role in the human body. Hemorrhage is a critical cause of both military and civilian casualties. The human body has its own hemostatic mechanism that involves complex processes and has limited capacity.
View Article and Find Full Text PDFCombination targeting of 'platelets + fibrin' enhances clot anchorage efficiency of nanoparticles for vascular drug delivery.
Nanoscale
November 2020
Case Western Reserve University, Department of Biomedical Engineering, Cleveland, OH 44106, USA.
Occlusive thrombosis is a central pathological event in heart attack, stroke, thromboembolism, etc. Therefore, pharmacological thrombolysis or anticoagulation is used for treating these diseases. However, systemic administration of such drugs causes hemorrhagic side-effects.
View Article and Find Full Text PDFRecent developments and clinical applications of surgical glues: An overview.
Int J Biol Macromol
September 2019
Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, V.L.Mehta Road, Vile Parle (W), Mumbai, Maharashtra 400056, India. Electronic address:
Novel developments in surgical glues for sealing wounds, surgical incision and tissue healing was inspired by limitations related to other surgical techniques. Sealants or bioadhesives are considered as a promising candidate over sutures, staples for sealing of air and gas leakages with minimal scarring in different surgeries. Their physical, biological properties and adhesive strength have encouraged many surgeons for employing them in clinical practice.
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