Hypertensive disorders of pregnancy (HDP), including preeclampsia (PE), are associated with short- and long-term maternal health complications, and obesity is a leading attributable risk factor for HDP. Yet, most women identified as obese [by body mass index (BMI) ≥ 30 kg/m] do not develop HDP, indicating limited predictability of BMI alone. In nonpregnant populations, increased visceral fat mass (VFM) is an obesity-associated phenotype increasing the risk of developing hypertension. We sought to assess whether, in pregnancy, obese women with PE would have higher circulating levels of adipokines preferential to VFM compared to obese women without PE. We performed a case-control study of women with and without PE, including obese ( = 65; BMI ≥ 30 kg/m) and normal weight ( = 52; BMI 18.4-24.9 kg/m) women. Plasma concentrations of adipokines preferential to VFM (visfatin, resistin), adipokines reflecting overall adiposity (leptin, adiponectin), and inflammatory cytokines were compared. We found that among obese women, cases had significantly higher levels of VFM-associated adipokines and cytokines compared to controls [visfatin ( < .01, = -3.8), resistin ( = .002, = 1.12), IFN gamma ( = .04, = -2.0), IL-6 ( < .01, = -2.65), IL1-beta ( < .01, = -4.1), IL-2 ( < .01, = -3.9)]. Interestingly, however, obese and normal weight cases had similar VFM-adipokine and cytokine levels [visfatin ( = .34, = -0.35), resistin ( = .55, = -0.25)], and inflammatory marker concentrations [IFN gamma ( = .86, = -0.76), IL-6 ( = .91, = -0.53), IL-1beta ( = .67, = 1.18), and IL-2 ( = .45, = -1.16)]. These data possibly suggest an association between VFM and PE that is present independent of BMI. In summary, we demonstrated that, in normal-weight and obese women, PE was associated with higher concentrations of VFM-preferential adipokines compared to normal-weight and obese controls without PE.
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http://dx.doi.org/10.1080/14767058.2018.1562542 | DOI Listing |
PLoS One
December 2024
Department of Nutrition, Addis Ababa Medical University College Hargeisa Campus, Hargeisa, Somaliland.
Background: Metabolic syndrome (met-s) is a medical condition that includes abdominal obesity, hyperlipidemia, high blood glucose, and high blood pressure. It is associated with a high risk of developing cardiovascular diseases and type 2 diabetes mellitus. The condition was believed to be a challenge mostly faced by developed nations.
View Article and Find Full Text PDFPLoS One
December 2024
Adjuncant Associate Clinical Professor School of Medicine, University of Limerick, Limerick, Ireland.
Background: All Indian ethnic groups are experiencing an upsurge in the prevalence of hypertension. The objective of the present study was to explore the association between socioeconomic and behavioral factors of hypertension among the tribal population of India.
Methods: We used the National Family Health Survey (NFHS) round 5 data conducted in 2019-2021.
Metabolites
December 2024
Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of fertile age. Some studies suggest that a ketogenic diet (KD) may have a role in treating PCOS. We aimed to demonstrate the long-term effectiveness of a KD in PCOS.
View Article and Find Full Text PDFMetabolites
November 2024
Innovation in Paediatrics and Technologies-iPEDITEC- Research Group, Fundación de Investigación, Consorcio Hospital General, University of Valencia, 46010 Valencia, Spain.
: Childhood obesity is a global health problem that affects at least 41 million children under the age of five. Increased BMI in children is associated with serious long-term health consequences, such as type 2 diabetes, cardiovascular disease, and psychological problems, including depression and low self-esteem. Although the etiology of obesity is complex, research suggests that the diet and lifestyle of pregnant women play a key role in shaping metabolic and epigenetic changes that can increase the risk of obesity in their children.
View Article and Find Full Text PDFJ Cardiovasc Dev Dis
November 2024
Health and Movement Consultation, Pediatric Cardiology Unit, Service of Pediatric Specialties, Department of Woman, Child and Adolescent Medicine, Geneva University Hospitals and Faculty of Medicine, University of Geneva, 1211 Geneva 14, Switzerland.
: In adults, epicardial adipose tissue (EAT) is associated with metabolic syndrome (MS) and coronary artery disease. EAT thickness is increased in obese youth, but total EAT volume and its correlation with cardiovascular risk factors have not been studied. : To determine EAT volume in adolescents and its association with obesity and cardiovascular risk factors.
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