Five new oxygenated sesquiterpenes, molestins A⁻D (, ⁻) and -gibberodione (), three new cyclopentenone derivatives, -sinulolides C, D, and F ((+)-⁻(+)-), one new butenolide derivative, -sinulolide H ((+)-), and one new cembranolide, molestin E (), together with 14 known related metabolites (⁻, (⁻)-⁻(⁻)-, (±)-, (⁻)-, ⁻) were isolated from the Paracel Islands soft coral cf. . The structures and absolute configurations were elucidated based on comprehensive spectroscopic analyses, quantum chemical calculations, and comparison with the literature data. Compound is the first example of a norsesquiterpene with a de-isopropyl guaiane skeleton isolated from the genus . Molestin E () exhibited cytotoxicities against HeLa and HCT-116 cell lines with IC values of 5.26 and 8.37 μM, respectively. Compounds , , and showed significant inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) with IC values of 218, 344, and 1.24 μM, respectively.
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