Endothelial to mesenchymal transition in atherosclerotic vascular remodeling.

Clin Chim Acta

Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerosis of Hunan Province, University of South, Hengyang City, Hunan Province 421001, PR China. Electronic address:

Published: March 2019

AI Article Synopsis

  • * Endothelial to mesenchymal transition (EndMT) represents a change in endothelial cells that can lead to conditions like vascular remodeling and myocardial fibrosis.
  • * Understanding the signaling pathways involved in EndMT could lead to new treatments for atherosclerosis and related diseases.

Article Abstract

Endothelial cells are the main components of the heart, blood vessels, and lymphatic vessels, which play an important role in regulating the physiological functions of the cardiovascular system. Endothelial dysfunction is involved in a variety of acute and chronic cardiovascular diseases. As a special type of epithelial-mesenchymal transition (EMT), endothelium to mesenchymal transition (EndMT) regulates the transformation of endothelial cells into mesenchymal cells accompanied by changes in the expression of various transcription factors and cytokines, which is closely related to vascular endothelial injury, vascular remodeling, myocardial fibrosis and valvar disease. Endothelial cells undergoing EndMT lose their endothelial characteristics and undergo a transition toward a more mesenchymal-like phenotype. However, the molecular mechanism of EndMT remains unclear. EndMT, as a type of endothelial dysfunction, can cause vascular remodeling which is a major determinant of atherosclerotic luminal area. Therefore, exploring the important signaling pathways in the process of EndMT may provide novel therapeutic strategies for treating atherosclerotic diseases.

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Source
http://dx.doi.org/10.1016/j.cca.2018.12.018DOI Listing

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