Biosynthesis of the uridine-derived nucleoside antibiotic A-94964: identification and characterization of the biosynthetic gene cluster provide insight into the biosynthetic pathway.

Org Biomol Chem

Biotechnology Research Center and Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo, 113-8567, Japan.

Published: January 2019

AI Article Synopsis

  • A-94964 is a uridine-derived nucleoside antibiotic derived from the bacterium Streptomyces sp. SANK 60404.
  • The researchers conducted gene deletion experiments and used computer-based analysis to understand the biosynthetic gene cluster related to A-94964.
  • This study sheds light on the distinctive biosynthetic pathway used to produce A-94964.

Article Abstract

The natural product A-94964 is a uridine-derived nucleoside antibiotic isolated from Streptomyces sp. SANK 60404. In this study, we propose a biosynthetic pathway for A-94964 using gene deletion experiments coupled with in silico analysis of the biosynthetic gene cluster. This study provides insights into the unique biosynthetic pathway for A-94964.

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Source
http://dx.doi.org/10.1039/c8ob02765jDOI Listing

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