Electrochemical Dehydrogenative Imidation of N-Methyl-Substituted Benzylamines with Phthalimides for the Direct Synthesis of Phthalimide-Protected gem-Diamines.

Org Lett

Beijing Key Laboratory of Environmental and Viral Oncology, College of Life Science & Bioengineering , Beijing University of Technology, Beijing 100124 , China.

Published: January 2019

A general and green electrochemical dehydrogenative method for the imidation of N-methyl benzylamines with phthalimides with excellent regioselectivities is reported for the first time. This operationally simple method offers a valuable tool to obtain structurally diverse phthalimide-protected gem-diamines.

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http://dx.doi.org/10.1021/acs.orglett.8b03624DOI Listing

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