AI Article Synopsis
- Screening for trisomy 18 in bichorial-biamniotic twin pregnancies involves ultrasound and non-invasive prenatal testing (NIPT) starting at 12 weeks, with amniocentesis required for definitive diagnosis.
- The management may include selective feticide during the first or third trimester, as trisomy 18 is often linked to maternal age-related chromosomal nondisjunction.
- This condition is serious, associated with a high stillbirth rate, but a few cases show that some babies can survive for several years.
Article Abstract
Screening for chromosomal abnormality such as trisomy 18 in a bichorial-biamniotic twin pregnancy is based on ultrasound and a non-invasive prenatal test (NIPT) from 12 weeks of gestation. An invasive examination such as amniocentesis is necessary for a diagnostic confirmation. The management of these complicated cases consists in performing a selective feticide in the first or third trimester of pregnancy. Trisomy 18 most often results from a chromosomal nondisjunction of maternal origin. Indeed, advanced maternal age is a major cause of chromosomal abnormality and a promoting factor of twin pregnancies. This is a severe condition with a very high stillbirth rate, even though there are certain cases where babies have managed to survive for several years.
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