Lymphocyte transformation, rosette formation and behaviour of immunoglobulins in sarcoidosis.

1. Patients with sarcoidosis indicated significant decrease of the mean value of lymphocyte transformation (LT) in all stages and all periods of sarcoidosis. In chronic sarcoidosis the mean value of LT was significantly lower (27.6%) than in the initial active stage I (44.6%) and increased among patients who recovered from sarcoidosis. 2. Patients suffering from sarcoidosis have depressed percentage of T lymphocytes compared to healthy subjects and depressed ability to lymphocytes blast transformation after PHA stimulation. No significant difference exists in the percentage of B cells detected by rosette formation with normal subjects. 3. The mean values of IgG, IgA and IgM in sarcoidosis patients were higher, and became normal after recovery. Levels of immunoglobulins were successively increased according to the stage. An increased IgG level is connected with active phase of the process whereas IgA is more stable but rised.