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Posterior subependymal germinal matrix hemorrhage as a mild form of hemorrhage in extremely preterm infants: neurodevelopmental outcomes at corrected ages of 18-24 months.
Ultrasonography
September 2024
Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Purpose: This study aimed to explore the effects of both the presence and size of posterior subependymal germinal matrix hemorrhage (PS-GMH), considered a mild form of hemorrhage, on the neurodevelopmental outcomes of extremely preterm infants.
Methods: A retrospective analysis was conducted on 221 extremely preterm infants, assessing their initial and term-equivalent age (TEA) cranial ultrasound (cUS) examinations from 2016 to 2021. Infants were classified based on the presence and size (small/large) of PS-GMH.
Low and sustained doses of erythropoietin prevent preterm infants from intraventricular hemorrhage.
Respir Physiol Neurobiol
January 2025
Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec City, Quebec, Canada; Brain Research Center, High Altitude Research Foundation, La Paz, Bolivia. Electronic address:
In addition to its hematopoietic function, erythropoietin (EPO) has demonstrated neuroprotective properties in preclinical studies, particularly in cases of reduced oxygenation or ischemia in the neonatal brain. While these findings have sparked optimism for its potential clinical application, the efficacy of EPO remains contentious in translational assays. Notably, while repeated administration of low doses of EPO has correlated with a decrease in adverse outcomes, the use of high EPO doses has shown either negligible or potentially detrimental effects on the incidence of brain injury.
View Article and Find Full Text PDFCerebellar haemorrhage and atrophy in infants born extremely preterm with intraventricular haemorrhage.
Dev Med Child Neurol
October 2024
Comprehensive Center for Pediatrics, Department of Pediatrics and Adolescent Medicine, Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Medical University of Vienna, Vienna, Austria.
Aim: To investigate the impact of cerebellar haemorrhage (CBH) and atrophy in infants born extremely preterm with intraventricular haemorrhage (IVH) on neurodevelopment at 2 years of age.
Method: This retrospective case-control study included infants born at less than 28 weeks' gestation with IVH over a 10-year period. CBH, along with the assessment of cerebellar size, using magnetic resonance imaging, were studied.
Outcomes after intranasal human milk therapy in preterm infants with intraventricular hemorrhage.
J Perinatol
October 2024
Division of Neonatology, The Hospital for Sick Children, Toronto, ON, Canada.
Article Synopsis
- Intraventricular hemorrhage (IVH) is a major cause of brain injury in preterm infants, and this study explores the potential benefits of intranasal human milk (IHM) for treating affected infants.
- The study involved 37 infants under 33 weeks gestation with IVH who received IHM until they were 28 days old, and their outcomes were compared to 191 historic controls fed with human milk.
- Preliminary results indicated that while post-hemorrhagic ventricular dilatation was common in IHM patients, most outcomes were more favorable for IHM at later ages, suggesting the need for more comprehensive trials in this area.
Improved Outcomes following a Conservative Approach to Hemodynamically Significant Patent Ductus Arteriosus: A Comparison across Two Periods.
Cardiology
September 2024
Department of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Introduction: Patent ductus arteriosus (PDA) is a commonly encountered morbidity that occurs inversely with gestational age. In response to the growing trend of avoiding PDA ligation and prophylactic interventions, our center adopted a conservative approach starting in September 2020. This approach involves more precise fluid restriction for hemodynamically significant (hs) PDA.
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