AI Article Synopsis
- The study explores drug repositioning to create zingerone nanoparticles (zingerone NPs) through a simple synthesis process.
- The zingerone NPs, which had a small size (1.42 ± 0.67 nm) and specific structure, were tested for their effects on human liver cancer cell lines (SK-Hep-1 and Huh7).
- Results showed that zingerone NPs inhibited key cancer cell pathways, leading to reduced tumor growth and promoting cell death, suggesting potential use in future cancer treatments.
Article Abstract
We base this study on the concept of drug repositioning to reconstitute the natural product of zingerone as zingerone nanoparticles (zingerone NPs) through a one-pot synthesized process. The as-fabricated zingerone NPs were characterized; they possessed a particle size of 1.42 ± 0.67 nm and a reconstituted structure of zingerone nanotetramer. We further validate the effects of zingerone NPs on the antitumor activity and investigate the relative underlying mechanisms on the human hepatoma SK-Hep-1 and Huh7 cell lines. Our results demonstrated that zingerone NPs significantly inhibit Akt activity and NFκB expression as well as activate the caspases cascade signaling pathway which are involved in the antiproliferation, antitumorigenicity, disturbing cell cycle progression, and induction of DNA damage as well as cell apoptosis. These findings were promising to provide a "Nano-chemoprevention" strategy in future cancer therapeutics and medical and clinical applications.
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| http://dx.doi.org/10.1021/acsami.8b14559 | DOI Listing |
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Article Synopsis
- The study explores drug repositioning to create zingerone nanoparticles (zingerone NPs) through a simple synthesis process.
- The zingerone NPs, which had a small size (1.42 ± 0.67 nm) and specific structure, were tested for their effects on human liver cancer cell lines (SK-Hep-1 and Huh7).
- Results showed that zingerone NPs inhibited key cancer cell pathways, leading to reduced tumor growth and promoting cell death, suggesting potential use in future cancer treatments.
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