AI Article Synopsis
- Current research indicates that VLCDCA 28:4 may serve as a potential blood-based biomarker for early colorectal cancer diagnosis, addressing a significant gap in current diagnostic methods.
- The study involved analyzing plasma levels of VLCDCA 28:4 in colorectal cancer patients from Italy and Brazil, as well as in patients with familial adenomatous polyposis, finding significant decreases in cancer patients but not in FAP patients.
- The findings suggest that lower levels of VLCDCA 28:4 could help identify sporadic colorectal cancer, and there may be therapeutic potential in restoring this compound for treatment.
Article Abstract
Background: There are currently no blood-based biomarkers for early diagnosis of colorectal cancer. Previous research has suggested that very-long-chain dicarboxylic acid (VLCDCA) 28:4 might be such a biomarker.
Methods: Using high-resolution mass spectrometry, we analyzed VLCDCA 28:4 in the plasma of colorectal cancer patients in Italian [ = 62] and Brazilian [ = 52] cohorts. Additionally, we investigated individuals diagnosed with familial adenomatous polyposis (FAP; = 27), one of the most important clinical forms of inherited susceptibility to colorectal cancer. Decrements in plasma levels of VLCDCA 28:4 were monitored in colorectal cancer patients. These decreases were independent of the stage of tumor development and the individual's age. However, no decrements in VLCDCA 28:4 were monitored in FAP patients.
Conclusions: The plasma levels of VLCDCA 28:4 represent a potential biomarker of sporadic colorectal cancer. In addition, it is possible that resupply of this anti-inflammatory lipid may represent a new therapeutic strategy for CRC and inflammatory disorders.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316647 | PMC |
| http://dx.doi.org/10.3390/metabo8040091 | DOI Listing |
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