The purpose of our study is to investigate the comparative effects of materials based on silver and gold nanoparticles functionalized with polyphenols from Cornus Mas extract (AgNPs-CM and AuNPs-CM) in vivo on experimental inflammation. The nanoparticles were obtained at room temperature under UV irradiation and were characterized by different methods: ultraviolet-visible spectroscopy, transmission electron microscopy, X ray diffraction, Fourier transform infrared spectroscopy and dynamic light scattering. The modulatory effects of AgNPs-CM and AuNPs-CM on inflammation were quantified by oxidative stress parameters, pro and anti-inflammatory cytokines levels and apoptosis assessment at 2 h, 24 and 48 h after induction of inflammation with carrageenan in the paw tissue of Wistar rats. Our results showed that silver and gold nanoparticles only partial and for a short period have mobilized the antioxidant defense mechanisms. In addition, they diminished inflammation and apoptosis in the early stage while later, at 48 h, exerted an immunomodulatory effect, activated ERK ½ and induced apoptosis. The photoreduced silver and gold nanoparticles, functionalized with natural compounds, modulated the inflammation in a similar manner in the soft tissue injected with carrageenan. In order to decipher the mechanisms involved in interactions of metallic nanoparticles with biological systems and for a complete assessment of the risks and benefits of these products in clinical practice long term studies are necessary.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jphotobiol.2018.12.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Enhancing photovoltaic efficiency in Half-Tandem MAPbI/ MASnI Perovskite solar cells with triple core-shell plasmonic nanoparticles.
Sci Rep
January 2025
Department of Electrical and Computer Engineering, Aarhus University, Aarhus, 8200, Denmark.
Significant progress has been made through the optimization of modelling and device architecture solar cells has proven to be a valuable and highly effective approach for gaining a deeper understanding of the underlying physical processes in solar cells. Consequently, this research has conducted a two-dimensional (2D) perovskite solar cells (PSCs) simulation to develop an accurate model. The approach utilized in this study is based on the finite element method (FEM).
View Article and Find Full Text PDFA simply synthesized, silver ions-doped porous gold microparticles-based SERS aptamer sensor for ultrasensitive and broad-range quantitative detection of IL-6.
Anal Chim Acta
January 2025
Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, China. Electronic address:
Background: The multifunctional cytokine interleukin-6 (IL-6) plays a pivotal role in chronic and acute inflammatory responses, underscoring the importance of accurately determining IL-6 levels for early diagnosis, prevention, and treatment of inflammation.
Results: This study developed a versatile and innovative single-particle surface-enhanced Raman spectroscopy (SERS) sensing platform for the precise and sensitive quantification of IL-6 in complex samples using a novel one-pot synthesized, silver ions-doped three-dimensional porous gold microparticles (PGMs) with abundant hot spots for robust SERS enhancement. By rationally designing rich cytosine-Ag-cytosine base pairs between IL-6 aptamers and complementary chains on the PGMs, we harnessed the SERS-enhancing effect to achieve highly sensitive and specific IL-6 quantification within a wide range of 10 to 10 mg/mL and a limit of detection (LOD) of 0.
Gold nanocages co-assembled with Spinacia oleracea extract combined photothermal/photodynamic therapy in 4T1 breast cancer cell line.
Biomed Mater
January 2025
Department of Biomedical Engineering, Indian Institute of Technology, Indian Institute of Technology Hyderabad, HYderabad, Telangana, 502284, INDIA.
Photothermal therapy (PTT) and photodynamic therapy (PDT) have been emerging as potential alternatives to conventional cancer treatment modalities. Gold nanoparticles, owing to their surface plasmon resonance properties, have been promising in cancer phototherapies, and extracts from potentially medicinal plants are commonly employed for the green synthesis of various nanoparticles. Some researchers also have been using chlorophyll as the photosensitizer for reactive oxygen species (ROS) generation.
View Article and Find Full Text PDFDeveloping Topics.
Alzheimers Dement
December 2024
Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Background: Previous models of resilience to Alzheimer's Disease (AD) have relied on cross-sectional designs and inclusion of measures of neuropathology. Here, we present a novel modeling approach incorporating longitudinal data and the use of APOE and higher order interaction terms to approximate neuropathological resilience, vastly increasing participant diversity and statistical power. We validate this approach and report novel genetic associations with neuropathological resilience.
View Article and Find Full Text PDFWhere Are All the Female Participants in Sports and Exercise Medicine Research? A Decade Later.
Am J Sports Med
January 2025
Department of Orthopedics and Sports Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
Background: In 2014, Costello and colleagues published a sentinel paper spotlighting the large disparity of female versus male representation within sports science and sports medicine (SSSM) research.
Purpose: To (1) revisit the method published by Costello et al a decade later to evaluate female representation and (2) ascertain whether study designs account for menstrual status.
Study Design: Systematic Review; Level of evidence, 4.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!