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Does Labetalol Trigger False Positive Drug Testing Results?
J Addict Med
June 2023
From the Department of Pathology, University of Utah, Salt Lake City, UT (NB, GAM); ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT (SDM, GAM).
Article Synopsis
- * The study tested labetalol in various concentrations across different specimen types (urine, plasma, meconium, and umbilical cord tissue) using validated drug tests, including immunoassay and LC-MS/MS.
- * Results revealed that while labetalol can generate false positives in immunoassays, no false positives occurred with the more accurate LC-MS/MS tests, indicating the importance of using specific testing methods.
Psychiatric and non-psychiatric drugs causing false-positive amphetamines urine test in psychiatric patients: a pharmacovigilance analysis using FAERS.
Expert Rev Clin Pharmacol
May 2023
Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, "Luigi Sacco" University Hospital, Università di Milano, Milan, Italy.
Introduction: Immunoassay urine drug screen (UDS) is frequently used in clinical practice for initial screening process, being generally available, fast, and inexpensive. Exposure to widely prescribed drugs might determine false-positive UDS amphetamines, leading to diagnostic issues, wrong therapeutic choices, impairment of physician-patient relationship, and legal implications.
Areas Covered: To summarize and comment on a comprehensive list of compounds responsible for UDS false positives for amphetamines, we conducted a literature review on PubMed along with a comparison with Real-World Data from the Food and Drug Administration Adverse Event Reporting System (FAERS) database analysis between 2010 and 2022.
Labetalol or Amphetamine: A Case of Mistaken Identity With Clinical Consequence.
Am J Ther
April 2020
Division of Cardiology, Westchester Medical Center and New York Medical College, Valhalla, NY.
Dual cocaine and methamphetamine cardiovascular toxicity: rapid resolution with labetalol.
Am J Emerg Med
March 2017
Department of Emergency Medicine, Oregon Health Sciences University, Oregon Poison Center, Portland, OR.
The sympathetic nervous system is controlled by transient receptor potential vanilloid 1 in the regulation of body temperature.
FASEB J
October 2015
*Institute of Pharmaceutical Science and British Heart Foundation Cardiovascular Centre of Excellence and Centre of Integrative Biomedicine, Cardiovascular Division, King's College London, London, United Kingdom
Transient receptor potential vanilloid 1 (TRPV1) is involved in sensory nerve nociceptive signaling. Recently, it has been discovered that TRPV1 receptors also regulate basal body temperature in multiple species from mice to humans. In the present study, we investigated whether TRPV1 modulates basal sympathetic nervous system (SNS) activity.
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