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An investigation of antiproliferative and antioxidant properties of crude extracts from Sedum nicaeense All. (Crassulaceae).
Pak J Pharm Sci
January 2025
Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan.
This study evaluated the antioxidant and antiproliferative effects of aqueous, ethanolic and methanolic extracts of Sedum nicaeense flowers and leaves. The MTT assay assessed cytotoxicity against colorectal cancer cells (Caco-2, HCT-116), breast cancer cells (T47D, MCF-7) and normal fibroblasts (MRC-5), while the ferric-reducing antioxidant power (FRAP) assay measured antioxidant capacity. Essential oils from flowers and leaves were analyzed using gas chromatography-mass spectrometry (GC-MS).
View Article and Find Full Text PDFPeruvian medical residency selection: a portrayal of scores, distribution, and predictors of 28,872 applicants between 2019 and 2023.
BMC Med Educ
January 2025
Centro de Investigación de Educación Médica y Bioética - EDUCAB-UPT, Facultad de Ciencias de la Salud, Universidad Privada de Tacna, Tacna, Peru.
Background: Residency selection is crucial for enhancing the healthcare workforce. Most research on this topic arises from the global north, leaving a gap from the global south perspective. Hence, this study aimed to evaluate factors associated with the Peruvian National Residency Examination (ENARM) in Peruvian applicants.
View Article and Find Full Text PDFObtaining personalized predictions from a randomized controlled trial on Alzheimer's disease.
Sci Rep
January 2025
TauRx Therapeutics, Aberdeen, Scotland.
The purpose of this article is to infer patient level outcomes from population level randomized control trials (RCTs). In this pursuit, we utilize the recently proposed synthetic nearest neighbors (SNN) estimator. At its core, SNN leverages information across patients to impute missing data associated with each patient of interest.
View Article and Find Full Text PDFSurrogate-assisted global and distributed local collaborative optimization algorithm for expensive constrained optimization problems.
Sci Rep
January 2025
Jiangxi Tellhow Power Technology Co., Ltd, Nanchang, 330031, China.
This paper presents a surrogate-assisted global and distributed local collaborative optimization (SGDLCO) algorithm for expensive constrained optimization problems where two surrogate optimization phases are executed collaboratively at each generation. As the complexity of optimization problems and the cost of solutions increase in practical applications, how to efficiently solve expensive constrained optimization problems with limited computational resources has become an important area of research. Traditional optimization algorithms often struggle to balance the efficiency of global and local searches, especially when dealing with high-dimensional and complex constraint conditions.
View Article and Find Full Text PDFSimultaneous activation of different subtypes of dopamine receptors may lead to activation of homeostatic sleep regulatory mechanisms.
Pharmacol Biochem Behav
January 2025
In vivo Electrophysiology Research Group, Department of Physiology and Neurobiology, Eötvös Loránd University, Hungary. Electronic address:
Dopaminergic system gains importance in homeostatic sleep regulation, but the role of different dopamine receptors is not well-defined. 72 h rat electrocorticogram and sleep recordings were made after single application of dopaminergic drugs in clinical use or at least underwent clinical trials. The non-selective agonist apomorphine evoked short pharmacological sleep deprivation with intense wakefulness followed by pronounced sleep rebound.
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