AI Article Synopsis
- Baboons immunized with radiation-attenuated cercariae show strong protection against schistosome infection, evidenced by high antibody levels targeting unknown schistosome antigens.
- Early anti-glycan IgM responses were noted after vaccination, but later vaccinations did not increase these levels, while anti-glycan IgG levels rose slowly and were boosted by subsequent vaccinations.
- After exposure to schistosomes, certain IgG levels, particularly those against complex glycans, remained elevated during the critical phase of parasite elimination, indicating their potential role in immune protection.
Article Abstract
Baboons vaccinated with radiation-attenuated cercariae develop high levels of protection against schistosome infection, correlating to high antibody titres towards schistosome antigens with unknown molecular identity. Using a microarray consisting of glycans isolated from different life-stages of schistosomes, we studied the anti-glycan immunoglobulin (Ig) G and IgM responses in vaccinated and challenged baboons over a time course of 25 weeks. Anti-glycan IgM responses developed early after vaccination, but did not rise in response to later vaccinations. In contrast, anti-glycan IgG developed more slowly, but was boosted by all five subsequent vaccinations. High IgM and IgG levels against O-glycans and glycosphingolipid glycans of cercariae were observed. At the time of challenge, while most antibody levels decreased in the absence of vaccination, IgG towards a subset of glycans containing multiple-fucosylated motifs remained high until 6 weeks post-challenge during challenge parasite elimination, suggesting a possible role of this IgG in protection.
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| http://dx.doi.org/10.1093/infdis/jiy714 | DOI Listing |
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