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Promise of Nucleic Acid Therapeutics for Amyotrophic Lateral Sclerosis.
Ann Neurol
January 2022
Department of Neurology, Keio University School of Medicine, Tokyo, Japan.
Nucleic acid therapeutics have been attracting attention as novel drug discovery modalities for intractable diseases, including amyotrophic lateral sclerosis. This review provides an overview of the current status and prospects of antisense oligonucleotide treatment for amyotrophic lateral sclerosis. Recently, the results of a phase I/II study using the antisense oligonucleotides Tofersen to treat familial amyotrophic lateral sclerosis with superoxide dismutase 1 mutation have been reported.
View Article and Find Full Text PDF"Bucket" cerebrospinal fluid bulk flow: when the terrain disagrees with the map.
Acta Neurochir (Wien)
February 2019
Department of Radiology and Nuclear Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
"Bucket" cerebrospinal fluid bulk flow-is it a fact or a fiction?
Acta Neurochir (Wien)
February 2019
Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, Cambridge University, Box 167, Addenbrookes Hospital, Cambridge, CB20QQ, UK.
The Liebau phenomenon: a translational approach to new paradigms of CSF circulation and related flow disturbances.
Childs Nerv Syst
February 2018
Department of Neurosurgery , Treviso Hospital , University of Padova, Piazza Ospedale 1, 31100, Treviso, Italia.
Purpose: The aim of the study is to provide a comparison between Liebau's effect, underlying the working principles of impedance pumps, and the cerebrospinal fluid (CSF) circulation.
Methods: Gerhard Liebau was a cardiologist with a specific interest in severe aortic regurgitation. Such interest drew his scientific attention to the flow-driven efficiency of valveless pumps.
A cytopreparatory method for cerebrospinal fluid in which the cell yield is high and the fluid is saved for chemical analysis.
Acta Cytol
June 1988
Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands.
A method for the concentration of cells from cerebrospinal fluid is described. An adaptation of a commercial cytochamber, consisting of a holder that fixes a disposable chamber directly on a microscope slide, was used. The cells were spun down in a conventional swing-out centrifuge, which was provided with a bucket for the cytochamber system.
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