AI Article Synopsis
- The study aimed to find out how common nonalcoholic fatty liver disease (NAFLD) is among obese children, estimating its prevalence and assessing the reliability of alanine aminotransferase (ALT) as a diagnostic tool.
- Approximately 26% of the 408 children assessed (aged 9-17) were found to have NAFLD, with higher rates in boys (29.4%) than girls (22.6%).
- The research determined effective ALT cut-off points for diagnosing NAFLD based on sex, achieving an overall diagnostic accuracy of 80% with a classification model that included sex, ALT levels, and insulin.*
Article Abstract
Objectives: To determine the prevalence of nonalcoholic fatty liver disease (NAFLD) in children with obesity because current estimates range from 1.7% to 85%. A second objective was to evaluate the diagnostic accuracy of alanine aminotransferase (ALT) for NAFLD in children with obesity.
Study Design: We evaluated children aged 9-17 years with obesity for the presence of NAFLD. Diseases other than NAFLD were excluded by history and laboratories. Hepatic steatosis was measured by liver magnetic resonance imaging proton density fat fraction. The diagnostic accuracy of ALT for detecting NAFLD was evaluated.
Results: The study included 408 children with obesity that had a mean age of 13.2 years and mean body mass index percentile of 98.0. The study population had a mean ALT of 32 U/L and median hepatic magnetic resonance imaging proton density fat fraction of 3.7%. The estimated prevalence of NAFLD was 26.0% (95% CI 24.2%-27.7%), 29.4% in male patients (CI 26.1%-32.7%) and 22.6% in female patients (CI 16.0%-29.1%). Optimal ALT cut-point was 42 U/L (47.8% sensitivity, 93.2% specificity) for male and 30 U/L (52.1% sensitivity, 88.8% specificity) for female patients. The classification and regression tree model with sex, ALT, and insulin had 80% diagnostic accuracy for NAFLD.
Conclusions: NAFLD is common in children with obesity, but NAFLD and obesity are not concomitant. In children with obesity, NAFLD is present in nearly one-third of boys and one-fourth of girls.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440815 | PMC |
| http://dx.doi.org/10.1016/j.jpeds.2018.11.021 | DOI Listing |
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