Objective: The amniotic membrane (AM) is a tissue with low immunogenity and high therapeutic potential due to its anti-inflammatory, anti-fibrotic and antimicrobial effects. This paper describes the use of cryopreserved amniotic membrane allografts to treat diabetic foot ulcers (DFUs) in patients with diabetes.
Method: In this case series, AM was processed to obtain a final medicinal product: cryopreserved amniotic membrane. cryopreserved AM was applied every 7-10 days until total epithelialisation of the DFUs.
Results: A total of 14 patients with DFUs (median size: 12.30cm, (range: 0.52-42.5cm) were treated and followed up until complete closure (median time: 20 weeks, range: 7-56 weeks). Patients received 4-40 AM applications. All patients in this study achieved complete epithelialisation of the wound. No adverse events were observed.
Conclusion: AM is a feasible and safe treatment in complex DFUs. Furthermore, the treatment is successful in achieving epithelialisation of long-evolution, unhealed wounds resistant to conventional therapies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.12968/jowc.2018.27.12.806 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Umbilical Cord Amniotic Membrane Graft as a Skin Substitute in Periocular Reconstruction: A Case Series.
Ophthalmic Plast Reconstr Surg
January 2025
Kahana Oculoplastic and Orbital Surgery, Livonia, Michigan.
Loss of periocular skin due to cancer, trauma, or surgery is a major reconstructive challenge; resultant tissue contracture can cause eyelid malposition with poor functional and aesthetic outcomes. We describe the successful use of cryopreserved umbilical cord amniotic membrane as a wound covering and scaffold for periorbital anterior lamellar defects. This is a retrospective case series of 4 patients (mean 21 years, range 9-30 years, 3 male) who underwent periocular reconstruction with umbilical cord amniotic membrane of 9 different sites.
View Article and Find Full Text PDFManagement of mucogingival defect following excision of multiple gingival squamous cell papillomas using VISTA - A case report with 24 months follow-up.
J Indian Soc Periodontol
December 2024
VISTA Institute for Therapeutic Innovations, California, USA.
Oral squamous cell papilloma is a benign proliferation of the stratified squamous epithelium, associated with the human papillomavirus (HPV). The clinical manifestation includes papillary or verrucous exophytic mass. Complete excision of the lesion, including normal margins, followed by histopathological examination is the treatment of choice.
View Article and Find Full Text PDFA Case of Sympathetic Ophthalmia After Corneal Perforation.
Cureus
November 2024
Ophthalmology, Tokyo Women's Medical University Adachi Medical Center, Tokyo, JPN.
We report a case of sympathetic ophthalmia that developed in the fellow eye following therapeutic corneal transplantation and amniotic membrane transplantation for corneal perforation caused by corneal ulceration. A 62-year-old man presented with discharge, lacrimation, and decreased visual acuity in the left eye. He was diagnosed with a corneal ulcer and treated with antimicrobial agents, but corneal epithelial erosion persisted, leading to nontraumatic corneal perforation.
View Article and Find Full Text PDFMaternal Colonization of Extended-Spectrum-Beta-Lactamase-Producing Enterobacteriaceae in Preterm Rupture of Membranes.
J Obstet Gynaecol Can
December 2024
Department of Obstetrics and Gynecology, Galilee Medical Center, Nahariya, Israel; Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel.
Aim: Maternal colonization by Enterobacteriaceae that produce extended-spectrum β-lactamases (ESBL-E) has risen, and the antimicrobial resistance of ESBL-E is significant. We aimed to evaluate the rates of ESBL-E colonization among women with preterm premature rupture of membranes (PPROM) and of maternal-neonatal vertical transmission. We also aimed to compare obstetrical and neonatal complications among ESBL-E positive versus negative maternal colonization in pregnancies complicated by PPROM.
View Article and Find Full Text PDFPterygium extended removal followed by minor ipsilateral simple limbal epithelial transplantation (PERMISLET): An innovative technique for recurrent pterygium.
Indian J Ophthalmol
December 2024
Department of Ophthalmology, Military Hospital, Panagarh, West Bengal, India.
We describe a novel technique for recurrent pterygium and assess the advantage of properties of extended tenonectomy, amniotic membrane transplantation, and limbal epithelial transplantation in terms of recurrence rate, postoperative symptoms, postoperative orthoptics, and other complications. A total of nine eyes with recurrent pterygium underwent PERMISLET, i.e.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!