Toward the development of the smart biosensing drug carrier, integration of dye molecules with polymeric chain has been an emerging method in recent years. In this perspective, dipyridamole (Dip)-based branched poly(l-lactide) (PLLA) and branched polycaprolactone (PCL) have been synthesized by ring-opening polymerization. After polymerization, the influence of the polyester chains on the Dip emission behavior has been studied systematically in this work. Dip-PLLA has undergone C=O···N=C interaction in ground stage, leading to intramolecular charge transfer in the excited state. Limited availability of the C=O in PCL chains resists such interactions with Dip molecule. So, this structural availability of the C=O group in the polymeric chains influences the color change between Dip-PLLA (green fluorescence) and Dip-PCL (blue fluorescence). To visualize the biosensing ability of Dip-PLLA and Dip-PCL, hollow microspheres have been prepared by the double-emulsion solvent evaporation method, and the prepared microspheres cells uptake has been visualized by fluorescence imaging.
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| http://dx.doi.org/10.1021/acsomega.8b01436 | DOI Listing |
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