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| http://dx.doi.org/10.1021/acscentsci.8b00706 | DOI Listing |
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Ten-year update of HOBOE phase III trial comparing triptorelin plus either tamoxifen or letrozole or zoledronic acid + letrozole in premenopausal hormone receptor-positive early breast cancer patients.
ESMO Open
January 2025
Clinical Trial Unit, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Naples, Italy. Electronic address:
Background: The Hormonal Bone Effects (HOBOE) study tested whether adjuvant triptorelin plus either letrozole (L) or zoledronic acid (Z) plus L (ZL) was more effective than tamoxifen (T) in premenopausal patients with hormone receptor-positive (HR+) early breast cancer (BC). Here we report the long-term follow-up analysis.
Patients And Methods: HOBOE (ClinicalTrials.
Betulin is a bioactive compound found in large quantities in birch bark and has a triterpene pentacyclic structure. Through the oxidation of betulin, betulinic acid is obtained, which is found in large quantities in nature. Betulin and betulinic acid have multiple pharmacological properties such as antiviral, anti-inflammatory, and anticancer properties.
View Article and Find Full Text PDFImpact of iron-folic acid supplementation on maternal and neonatal outcomes: A systematic review & meta-analysis.
Nutr Health
November 2024
Clinical Research Unit, All India Institute of Medical Sciences, New Delhi, India.
Iron-folic acid (IFA) supplementation is widely recommended as both a preventive and therapeutic measure for pregnant women. Despite its widespread use, there is limited research exploring adherence to IFA supplementation during pregnancy and its impact on maternal and neonatal outcomes. This study aims to assess the effectiveness of IFA supplementation in improving pregnancy and neonatal outcomes.
View Article and Find Full Text PDFHigh-dose folic acid use and cancer risk in women who have given birth: A register-based cohort study.
Epilepsia
January 2025
Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Article Synopsis
- The study aimed to investigate if high-dose folic acid (>1 mg daily) use in women who have given birth and those with epilepsy is linked to a higher risk of cancer, especially in children born to mothers with epilepsy.
- Researchers analyzed data from medical birth registers in Denmark, Norway, and Sweden, tracking cancer diagnoses among women over time while taking into account other factors like antiseizure medication use.
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D epartment of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
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