AI Article Synopsis
- Animals adjust their metabolism throughout their life cycle, and in Drosophila, the dHNF4 nuclear receptor initiates a crucial switch in lipid metabolism at the beginning of adulthood.
- This switch converts lipid stores into long chain fatty acids and hydrocarbons that help waterproof the insect and maintain fluid balance.
- The dHNF4 pathway not only promotes longevity and resistance to dehydration but also helps manage issues related to diabetes, highlighting its evolutionary significance.
Article Abstract
Animals must adjust their metabolism as they progress through development in order to meet the needs of each stage in the life cycle. Here, we show that the dHNF4 nuclear receptor acts at the onset of Drosophila adulthood to direct an essential switch in lipid metabolism. Lipid stores are consumed shortly after metamorphosis but contribute little to energy metabolism. Rather, dHNF4 directs their conversion to very long chain fatty acids and hydrocarbons, which waterproof the animal to preserve fluid homeostasis. Similarly, HNF4α is required in mouse hepatocytes for the expression of fatty acid elongases that contribute to a waterproof epidermis, suggesting that this pathway is conserved through evolution. This developmental switch in Drosophila lipid metabolism promotes lifespan and desiccation resistance in adults and suppresses hallmarks of diabetes, including elevated glucose levels and intolerance to dietary sugars. These studies establish dHNF4 as a regulator of the adult metabolic state.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351194 | PMC |
| http://dx.doi.org/10.1016/j.devcel.2018.11.030 | DOI Listing |
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