AI Article Synopsis
- The study aimed to compare the effects of epidermal growth factor (EGF) treatment versus observation on healing human tympanic membrane perforations (TMP).
- It involved 44 patients, with the EGF group showing a much higher closure rate (96.2%) and faster healing time (mean 9.1 days) compared to the observation group (61.1% closure and mean 20.6 days).
- The research concluded that EGF treatment significantly enhances TMP healing without the need for invasive procedures, making it a recommended option before undergoing surgery.
Article Abstract
Objective: To compare the effects of epidermal growth factor (EGF) and observation only on human subacute tympanic membrane perforation (TMP).
Methods: A total of 44 patients with traumatic TMPs >2 months after trauma were divided into an observation group (n = 18) and EGF group (n = 26). Patients in the EGF group underwent direct application of EGF without stripping of the perforation edge. All patients were followed up for at least 6 months. The TMP closure rate, closure time, and hearing gain were evaluated.
Results: At 6 months, 25 of 26 (96.2%) perforations achieved complete closure with a mean closure time of 9.1 ± 3.9 days (range, 3-14 days) in the EGF group. However, only 11 of 18 (61.1%) perforations achieved complete closure in the observation group, with a mean closure time of 20.6 ± 10.7 days (range = 9-71 days). The patients in the EGF-treated group had significantly improved closure rates (P = 0.026) and a reduced closure time (P < 0.01) compared to those in the observation group. The difference in mean hearing improvement between the two groups was not statistically significant (P = 0.86).
Conclusions: Topical application of EGF improved the closure rate and shortened the closure time of human subacute TMPs compared with spontaneous healing, the stripping of the perforation edge was unnecessary. This treatment is simple and convenient and should be recommended pre-myringoplasty.
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| http://dx.doi.org/10.1016/j.amjoto.2018.11.011 | DOI Listing |
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