AI Article Synopsis
- The study developed a new drug delivery system using organogels (ORGs) that combined oleic acid-lanolin, poloxamer, and lidocaine to evaluate their properties and effectiveness.
- The results showed that varying the concentrations of lanolin and poloxamer changed the physical properties of the organogels and influenced the release rates of lidocaine.
- The ORG system demonstrated low cytotoxicity and provided longer-lasting local anesthesia effects, suggesting it could be a better alternative for delivering topical anesthetics compared to current options.
Article Abstract
The aim of this study was to synthesize a novel drug delivery system using organogels (ORGs) and characterize its physicochemical properties, in vitro and ex vivo permeation abilities, cytotoxicity and in vivo local anesthetic effects. The ORG formulations contained a mixture of oleic acid-lanolin (OA-LAN), poloxamer (PL407), and the commonly used local anesthetic lidocaine (LDC). The main focus was to evaluate the impact of LAN and PL407 concentrations on the ORG structural features and their biopharmaceutical performance. Results revealed that LDC, OA, and LAN incorporation separately shifted the systems transitions phase temperatures and modified the elastic/viscous moduli relationships (G'/G″ = ~15×). Additionally, the formulation with the highest concentrations of LAN and PL407 reduced the LDC flux from ~17 to 12 μg·cm·h and the permeability coefficients from 1.2 to 0.62 cm·h through ex vivo skin. In vivo pharmacological evaluation showed that the ORG-based drug delivery system presented low cytotoxicity, increased and prolonged the local anesthetic effects compared to commercial alternatives. The data from this study indicate that ORG represent a promising new approach to effectively enhance the topical administration of local anesthetics.
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| http://dx.doi.org/10.1016/j.ejps.2018.12.009 | DOI Listing |
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