Objectives: The objectives of this study were to: (1) develop a novel multifunctional composite with nanoparticles of silver (NAg), 2-methacryloyloxyethyl phosphorylcholine (MPC), dimethylaminohexadecyl methacrylate (DMAHDM) and nanoparticles of amorphous calcium phosphate (NACP); and (2) investigate biofilm-inhibition via the multifunctional nanocomposite against three species of periodontal pathogens for the first time.
Methods: The multifunctional nanocomposite was fabricated by incorporating NAg, MPC, DMAHDM and NACP into the resin consisting of pyromellitic glycerol dimethacrylate (PMDGDM) and ethoxylated bisphenol A dimethacrylate (EBPADMA). Three species (Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum) were tested for metabolic activity (MTT), live/dead staining, polysaccharide production and colony-forming units (CFU) of biofilms grown on resins.
Results: Incorporation of 0.08% to 0.12% NAg, 3% MPC, 3% DMAHDM and 30% NACP did not compromise the mechanical properties of the composite (p > 0.1). The multifunctional nanocomposite reduced protein adsorption to nearly 1/10 of that of a commercial control (p < 0.05). For all three species, the biofilm CFU was reduced by about 5 and 1 orders of magnitude via the nanocomposite containing NAg + MPC + DMAHDM, compared to commercial control and the composite with MPC + DMAHDM, respectively.
Conclusions: The novel multifunctional nanocomposite achieved the greatest reduction in metabolic activity, polysaccharide and biofilm growth of three periodontal pathogens.
Clinical Significance: The strongly-antibacterial, multifunctional composite is promising for treating root lesions, alleviating periodontitis and protecting the periodontal tissues.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jdent.2018.12.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A novel skin-like patch based on 3D hydrogel nanocomposite of Polydopamine/TiO nanoparticles and Ag quantum dots accelerates diabetic wound healing compared to stem cell therapy.
J Tissue Viability
December 2024
Institute of Nanoscience & Nanotechnology, Kafrelsheikh University, Kafr ElSheikh, 33516, Egypt; Nile Valley University, Fayoum, 63518 Egypt. Electronic address:
Despite the advances in the development of therapeutic wearable wound-healing patches, lack self-healing properties and strong adhesion to diabetic skin, hindering their effectiveness. We propose a unique, wearable patch made from a 3D organo-hydrogel nanocomposite containing polydopamine, titanium dioxide nanoparticles, and silver quantum dots (PDA-TiO@Ag). The designed patch exhibits ultra-stretchable, exceptional-self-healing, self-adhesive, ensuring conformal contact with the skin even during movement.
View Article and Find Full Text PDFEditorial for Special Issue: "Thin Films Based on Nanocomposites (2nd Edition)".
Nanomaterials (Basel)
December 2024
National Institute of Materials Physics, 405A Atomistilor Street, P.O. Box MG-7, 077125 Magurele, Romania.
The continuous demand for multifunctional materials in industrial applications has driven the design of nanocomposites with new or enhanced properties [...
View Article and Find Full Text PDFCharacteristics and Antitumor Activity of Doxorubicin-Loaded Multifunctional Iron Oxide Nanoparticles in MEC1 and RM1 Cell Lines.
J Funct Biomater
December 2024
Division of Immunology and Microbiology, Iv. Javakhishvili Tbilisi State University, 1, Ilia Tchavchavadze Ave., 0179 Tbilisi, Georgia.
The rapid progress in nanotechnology has introduced multifunctional iron oxide nanoparticles as promising agents in cancer treatment. This research focused on the synthesis and assessment of citric-acid-coated, folic-acid-conjugated nanoparticles loaded with doxorubicin, evaluating their therapeutic potential in tumor models. An advanced automated continuous technology line (CTL) utilizing a controlled co-precipitation method was employed to produce highly dispersive, multifunctional nanofluids with a narrow size distribution.
View Article and Find Full Text PDFInjectable dual-network hyaluronic acid nanocomposite hydrogel for prevention of postoperative breast cancer recurrence and wound healing.
Int J Biol Macromol
December 2024
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin 541001, PR China.
High locoregional recurrence rates and potential wound infections remain a significant challenge for postoperative breast cancer patients. Herein, we developed a dual-network hyaluronic acid (HA) nanocomposite hydrogel composed of herring sperm DNA (hsDNA) bridged methacrylated HA (HAMA) and FeMg-LDH-ppsa nanohybrid chelated catechol-modified HA (HADA) for the prevention of breast cancer recurrent, anti-infection, and promoting wound healing. Dynamic reversible hsDNA cross-linking combined with metal-catechol chelating renders the hydrogel injectability, rapid self-healing ability, and enhanced mechanical properties.
View Article and Find Full Text PDFThermal Transfer Printed Flexible and Wearable Bionic Skin with Bilayer Nanofiber for Comfortable Multimodal Health Management.
Adv Healthc Mater
December 2024
Department of Biomedical Engineering, City University of Hong Kong, Kowloon, Hong Kong SAR, 999077, China.
The advent of bionic skin sensors represents a significant leap forward in the realm of wearable health monitoring technologies. Existing bionic skin technologies face several limitations, including complex and expensive manufacturing processes, low wearing comfort, and challenges in achieving comfortable real-time health monitoring. These shortcomings hinder the widespread adoption and practical utility of bionic skin in various applications.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!