Background: The purpose of this study was to evaluate the midterm and long-term clinical outcomes of aortic implantation of stent grafts under direct vision (hybrid surgical treatment).
Methods: From March 2009 to December 2014, 285 patients presented with type B aortic dissection. Of these, 35 complicated patients underwent hybrid surgical treatment. Self-designed stent grafts (Micropart Corp, Shanghai, China) were implanted under direct vision. Collected data included the surgical time, cerebral perfusion time, aortic clamping time, postoperative (before discharge) mechanical ventilation time, consciousness recovery time, time in intensive care unit, length of stay, computed tomography angiography before discharge, middle- and long-term complications, mortality, and endoleaks.
Results: All of the 35 implantations were successful. There was no inhospital mortality, reexploration for hemorrhage, paraplegia, cerebral infarction, endoleaks, nor left subclavian artery occlusions. Computed tomography angiography before discharge showed complete thrombosis of the false lumen of the descending aortic in 34 patients. During the longer follow-up of 5.05 ± 3.61 years (range, 3.0 to 10), 3 patients were lost to follow-up. Three patients died during follow-up: 1 died in a traffic accident and 2 died of sudden death. The actuarial survival among all patients was 90.63% during the long-term follow-up. No events such as paraplegia, cerebral infarction, upper limb ischemia, endoleaks, or left subclavian artery ischemia were found. One patient had descending aneurysm at the distal stent graft and underwent another thoracic endovascular aortic repair without additional procedures.
Conclusions: For patients with complicated type B aortic dissection, implantation of a stent graft under direct vision (hybrid surgery) is easily performed and provides satisfactory middle- and long-term outcomes.
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http://dx.doi.org/10.1016/j.athoracsur.2018.11.023 | DOI Listing |
Biomed Chromatogr
February 2025
Department of Pharmacy, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
The aim of this study was to investigate the potential mechanism of Lu-Jiao Fang (LJF) inhibiting endothelial-to-mesenchymal transition (EndMT) in pressure overload-induced cardiac fibrosis. Pharmacokinetic behaviors of the ingredients of LJF were evaluated by LC-MS/MS analysis. Then putative pathways by which LJF regulates EndMT were analyzed by network pharmacology and verified in transverse aortic constriction-induced cardiac fibrosis rats.
View Article and Find Full Text PDFJ Am Coll Cardiol
November 2024
Elite Centre for Individualized Medicine in Arterial Disease, Odense University Hospital, Odense, Denmark; Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Background: Prospective data on the clinical course of the ascending thoracic aorta are lacking.
Objectives: This study sought to estimate growth rates of the ascending aorta and to evaluate occurrences of adverse aortic events (AAEs)-that is, thoracic aortic ruptures, type A aortic dissections, and thoracic aortic-related deaths.
Methods: In this prospective cohort study from the population-based, multicenter, randomized DANCAVAS (Danish Cardiovascular Screening trials) I and II, participants underwent cardiovascular risk assessments including electrocardiogram-gated, noncontrast computed tomography (CT) scans.
Nutrients
December 2024
Institute for Health and Sport, Victoria University, Melbourne, VIC 3030, Australia.
Background: Obesity is a risk factor for developing cardiovascular diseases (CVDs) by impairing normal vascular function. Natural products are gaining momentum in the clinical setting due to their high efficacy and low toxicity. extract (CFE) has been shown to control appetite and promote weight loss; however, its effect on vascular function remains poorly understood.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Department of Pharmacology, Pharmacy College, Nantong University, Nantong 226001, China.
This research seeks to investigate the function and fundamental mechanisms of Itchy E3 ubiquitin ligase (ITCH), a HECT (homologous to E6AP carboxyl terminus)-type E3 ubiquitin ligase, in endothelial ferroptosis, particularly in the context of atherosclerosis, which has been underexplored. The levels of ITCH protein in the aortas of mice with atherosclerosis were analyzed. Constructs for ITCH RNA interference were generated and introduced into human aortic endothelial cells (HAECs).
View Article and Find Full Text PDFMedicina (Kaunas)
December 2024
Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
: Resistance exercises (REs) are a type of physical activity that individuals from many age groups have been doing recreationally, both as amateurs and professionally, in their daily lives in recent years. It is crucial to understand the effects of such sports on cardiac morphology in order to maximize the benefit of training and to tailor the training content accordingly. The aim of this study was to investigate the relationship between training experience (TE) and left ventricular (LV) systolic and diastolic parameters and left atrial (LA) mechanical function in healthy subjects who regularly performed RE for different durations.
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