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Effect of 800 IU Versus 2000 IU Vitamin D3 With or Without a Simple Home Exercise Program on Functional Recovery After Hip Fracture: A Randomized Controlled Trial. | LitMetric
Department of Geriatrics and Aging Research, University Hospital Zurich and University of Zurich, Switzerland; Centre on Aging and Mobility, University Hospital Zurich and City Hospital Waid Zurich, Switzerland; University Clinic for Acute Geriatric Care, City Hospital Waid, Zurich, Switzerland. Electronic address:
Published: May 2019
AI Article Synopsis
Article Abstract
Objectives: To evaluate 2 simple strategies, vitamin D and a home exercise program, in functional recovery during the first year after hip fracture.
Design: Secondary analysis of a factorial clinical trial. Patients were randomly allocated to 800 IU (standard of care) or 2000 IU vitamin D and a daily instruction of a simple home exercise program (SHEP) or standard physiotherapy alone during acute care.
Setting And Participants: Acute hip fracture patients aged ≥65 years, after hip fracture surgery, admitted to a large hospital in Zurich, Switzerland.
Measures: Three objective measures of lower extremity function were assessed at baseline and 6 and 12 months, with the Timed Up and Go test (TUG) as the primary endpoint, and knee flexor and extensor strength, and a self-reported physical function score (PF-10) as secondary endpoints. Linear mixed model regression analyses were based on intention to treat, adjusting for baseline function, time, age, sex, and baseline 25-hydroxyvitamin D level.
Results: We enrolled 173 patients (79.2% women; mean age 84 years; 77.5% living at home). A significant interaction was found between vitamin D dose and SHEP for TUG (P = .045). Thus, findings compared the standard of care reference arm with 800 IU vitamin D without SHEP to 3 interventions arms (800 IU vitamin D+SHEP; 2000 IU vitamin D without SHEP; 2000 IU vitamin D+SHEP). For TUG, over 12 months the 800 IU vitamin D+SHEP group performed significantly better than the standard-of-care group (13.8 vs 19.5 seconds; P = .01). Findings for knee flexor strength were in line with TUG results and approached significance (P = .07), whereas knee extensor strength and PF-10 did not differ by treatments.
Conclusions/implications: For functional recovery after hip fracture, combining home exercise with 800 IU vitamin D is superior to no home exercise or 2000 IU vitamin D. None of the interventions improved subjective physical functioning.
