Introduction: Accurate reference intervals (RIs) are essential for clinical interpretation of laboratory test results; however, major gaps exist in pediatric RIs. The Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) has established age- and sex-specific pediatric RIs on various analytical platforms. The current study expands the CALIPER database by establishing age- and sex-specific RIs for biochemical assays on Siemens ADVIA XPT/1800 and Dimension EXL Systems.
Methods: Serum samples from a total of 909 and 867 healthy children and adolescents (ages 0-<19 y) were tested on ADVIA XPT/1800 and Dimension EXL systems, respectively. Age- and/or sex-specific RIs were calculated for a total of 54 biochemical assays.
Results: Serum concentrations of several biomarkers remained relatively constant across the pediatric age range and similar between sexes, including sodium and triglycerides. Other biomarkers, such as alkaline phosphatase and creatinine showed both age and sex differences. Furthermore, immunoglobulin A and iron showed only age differences.
Discussion: We established RIs for creatine kinase, random glucose, total iron binding capacity, and several electrolytes for the first time using the CALIPER cohort. Overall, pediatric RIs established in the current study will allow for more accurate laboratory test interpretation worldwide using Siemens chemistry assays.
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