Strains of , and to a lesser extent other staphylococcal species, are a significant cause of morbidity and mortality. An important factor in the notoriety of these organisms stems from their frequent resistance to many antimicrobial agents used for chemotherapy. This review catalogues the variety of mobile genetic elements that have been identified in staphylococci, with a primary focus on those associated with the recruitment and spread of antimicrobial resistance genes. These include plasmids, transposable elements such as insertion sequences and transposons, and integrative elements including ICE and SCC elements. In concert, these diverse entities facilitate the intra- and inter-cellular gene mobility that enables horizontal genetic exchange, and have also been found to play additional roles in modulating gene expression and genome rearrangement.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633639 | PMC |
| http://dx.doi.org/10.1128/microbiolspec.GPP3-0030-2018 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Genetic and species rearrangements in microbial consortia impact biodegradation potential.
ISME J
January 2025
Universidad Pablo de Olavide, Centro Andaluz de Biología del Desarrollo/ Consejo Superior de Investigaciones Científicas/ Junta de Andalucía, Seville, Spain.
Genomic reorganisation between species and horizontal gene transfer have been considered the most important mechanism of biological adaptation under selective pressure. Still, the impact of mobile genes in microbial ecology is far from being completely understood. Here we present the collection and characterisation of microbial consortia enriched from environments contaminated with emerging pollutants, such as non-steroidal anti-inflammatory drugs.
View Article and Find Full Text PDFGenomic and mutational analysis of Pseudomonas syringae pv. tagetis EB037 pathogenicity on sunflower.
BMC Microbiol
January 2025
USDA-ARS, Sustainable Agricultural Systems Laboratory, Beltsville Agricultural Research Center, Beltsville, MD, 20705, USA.
Background: Pseudomonas syringae pv. tagetis (Pstag) causes apical chlorosis on sunflower and various other plants of the Asteraceae family. Whole genome sequencing of Pstag strain EB037 and transposon-mutant derivatives, no longer capable of causing apical chlorosis, was conducted to improve understanding of the molecular basis of disease caused by this pathogen.
View Article and Find Full Text PDFCRISPR in mobile genetic elements: counter-defense, inter-element competition and RNA-guided transposition.
BMC Biol
December 2024
Computational Biology Branch, Division of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD, 20894, USA.
CRISPR are adaptive immunity systems that protect bacteria and archaea from viruses and other mobile genetic elements (MGE) via an RNA-guided interference mechanism. However, in the course of the host-parasite co-evolution, CRISPR systems have been recruited by MGE themselves for counter-defense or other functions. Some bacteriophages encode fully functional CRISPR systems that target host defense systems, and many others recruited individual components of CRISPR systems, such as single repeat units that inhibit host CRISPR systems and CRISPR mini-arrays that target related viruses contributing to inter-virus competition.
View Article and Find Full Text PDFAntimicrobial resistance genes and associated mobile genetic elements in Escherichia coli from human, animal and environment.
Chemosphere
December 2024
ICAR-National Dairy Research Institute (NDRI), Animal Biotechnology Division, Animal Genomics Lab, Karnal, 132001, Haryana, India. Electronic address:
The global rise of antimicrobial resistance (AMR) poses a significant threat to human health. The environment plays an essential role in transmission of antimicrobial resistance genes (ARGs) between human and animal. Bacterial communities harbour diverse ARGs, carried by mobile genetic elements (MGEs) like plasmids and insertion sequences (ISs).
View Article and Find Full Text PDFSpatiotemporal and genomic analysis of carbapenem resistance elements in Enterobacterales from hospital inpatients and natural water ecosystems of an Irish city.
Microbiol Spectr
January 2025
Antimicrobial Resistance and Microbial Ecology Group, School of Medicine, University of Galway, Galway, Ireland.
Article Synopsis
- Carbapenemase-producing Enterobacterales (CPE) are multidrug-resistant bacteria that can spread their resistance genes via mobile genetic elements, complicating infection control efforts.
- A study in Galway, Ireland involved whole-genome sequencing of CPE samples from patients and wastewater to understand the distribution and characteristics of these organisms and their resistance genes.
- Findings revealed that most resistance genes were found on plasmids, with specific plasmid types associated with different CPE strains, highlighting the genetic mechanisms facilitating the spread of resistance between humans and the environment.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!