AI Article Synopsis
- Glycated hemoglobin (A1c) and glycated albumin (GA) are key indicators of blood sugar control, and this study focused on whether prednisolone (PSL) affects GA levels.
- Using multivariate analysis on 48 patients with connective tissue diseases (CTDs), researchers found that factors like PSL dosage, age, BMI, and A1c were significantly related to GA levels.
- The results indicated that participants taking higher doses of PSL (≥ 5 mg) had notably lower GA levels compared to those on lower doses, suggesting PSL may reduce GA concentration more significantly than it affects overall glycemia.
Article Abstract
Introduction: Glycated hemoglobin (A1c) and glycated albumin (GA) are often used as indicators of glycemic control. In this study, we determined whether prednisolone (PSL) administration lowers plasma GA.
Methods: We investigated the factors affecting GA using multivariate analysis in 48 subjects with connective tissue diseases (CTDs).
Results: Multiple regression analysis of GA showed that the dose of PSL [β = - 1.36; 95% confidence interval (CI) - 2.59 to - 0.14; p = 0.03], age (β = 0.06; 95% CI 0.03-0.09; p < 0.001), body mass index (BMI) (β = - 0.14; 95% CI - 0.28 to - 0.01; p = 0.042), and A1c (β = 1.4; 95% CI 0.38-2.42; p = 0.008) significantly correlated with GA (adjusted R = 0.518). Moreover, GA levels adjusted for age, sex, BMI, plasma albumin (Alb) and creatinine (Cre), and A1c in the subjects taking ≥ 5 mg PSL was significantly lower than those in those taking < 5 mg PSL. Finally, the dose of PSL (as a continuous variable) was negatively correlated with GA adjusted for age, sex, BMI, Alb, Cre, and A1c.
Conclusion: High dose (≥ 5 mg) PSL reduces GA concentration more than glycemia.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349290 | PMC |
| http://dx.doi.org/10.1007/s13300-018-0552-8 | DOI Listing |
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