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CircUCK2(2,3) promotes cancer progression and enhances synergistic cytotoxicity of lenvatinib with EGFR inhibitors via activating CNIH4-TGFα-EGFR signaling.
Cell Mol Biol Lett
January 2025
Clinical Research Center, Jiading District Central Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, 201800, China.
Background: Circular (circ)RNAs have emerged as crucial contributors to cancer progression. Nonetheless, the expression regulation, biological functions, and underlying mechanisms of circRNAs in mediating hepatocellular carcinoma (HCC) progression remain insufficiently elucidated.
Methods: We identified circUCK2(2,3) through circRNA sequencing, RT-PCR, and Sanger sequencing.
[Posterior Decompression Surgery for Degenerative Lumbar Disease:Basic Principles and Advantages/Disadvantages of Exoscopic Surgery].
No Shinkei Geka
January 2025
Department of Neurosurgery, Tominaga Hospital.
This paper examines advancements in minimally invasive posterior decompression techniques for lumbar degenerative diseases. It focuses on the unilateral approach for bilateral decompression and bilateral approach for contralateral decompression, in which the entry side is determined independently of the symptomatic side to achieve a facet joint preservation rate of ≥ 70%, while also emphasizing contralateral foraminal decompression(CFD). These techniques address spinal instability by minimizing facet joint resection, reducing postoperative instability.
View Article and Find Full Text PDFModelling epidemiological dynamics with pseudo-recovery via fractional-order derivative operator and optimal control measures.
PLoS One
January 2025
Department of Pure and Applied Mathematics, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
In this study, a new deterministic mathematical model based on fractional-order derivative operator that describes the pseudo-recovery dynamics of an epidemiological process is developed. Fractional-order derivative of Caputo type is used to examine the effect of memory in the spread process of infectious diseases with pseudo-recovery. The well-posedness of the model is qualitatively investigated through Banach fixed point theory technique.
View Article and Find Full Text PDFEnhancing the impact of psychological research on aging and adult lifespan development.
Psychol Aging
February 2025
Wilhelm Wundt Institute of Psychology, Leipzig University.
In this editorial, I outline two key changes to the submission guidelines, and I present my vision as the new editor for Psychology and Aging, the premier outlet for psychological research on aging and adult lifespan development. To enhance the impact of research published in the journal, my editorial team and I will accept articles that make strong theoretical contributions, are methodologically rigorous and transparent, use open science practices, contribute cumulative knowledge to the field, and have important practical implications. We will continue to publish high-quality empirical articles, systematic reviews, and meta-analyses, as well as theory development and methodological articles from all areas of psychology and related disciplines that focus on basic principles of aging and adult lifespan development or that investigate these principles in applied settings.
View Article and Find Full Text PDFFrom trade-off to synergy: how nutrient status modulates plant resistance to herbivorous insects?
Adv Biotechnol (Singap)
October 2024
State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Stress Biology, School of Agriculture and Biotechnology, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, 518107, China.
The principle of the "growth-defense trade-off" governs how plants adjust their growth and defensive strategies in response to external factors, impacting interactions among plants, herbivorous insects, and their natural enemies. Mineral nutrients are crucial in modulating plant growth and development through their bottom-up effects. Emerging evidence has revealed complex regulatory networks that link mineral nutrients to plant defense responses, influencing the delicate balance between growth and defense against herbivores.
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