AI Article Synopsis
- OCD patients struggle to transition from obsessive thoughts to compulsive behaviors, possibly due to issues with the salience network (SN) in the brain.
- The study examined intra- and inter-network connectivity of the SN in 40 drug-naïve OCD patients compared to 40 healthy controls using resting-state fMRI.
- Results showed decreased connectivity within the SN and reduced interaction between the SN and other brain networks, suggesting unique dysfunctions in brain organization for those with OCD.
Article Abstract
Obsessive-compulsive disorder (OCD) patients have difficulty in switching between obsessive thought and compulsive behavior, which may be related to the dysfunction of the salience network (SN). However, little is known about the changes in intra- and inter- intrinsic functional connectivity (iFC) of the SN in patients with OCD. In this study, we parceled the SN into 19 subregions and investigated iFC changes for each of these subregions in 40 drug-naïve patients with OCD and 40 healthy controls (HCs) using seed-based functional connectivity resting-state functional magnetic resonance imaging (rs-fMRI). We found that patients with OCD exhibited decreased iFC strength between subregions of the SN, as well as decreased inter-network connectivity between SN and DMN, and ECN. These findings highlight a specific alteration in iFC patterns associated with SN in patients with OCD and provide new insights into the dysfunctional brain organization of the SN in patients with OCD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279930 | PMC |
| http://dx.doi.org/10.3389/fnins.2018.00889 | DOI Listing |
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