AI Article Synopsis
- The apoE4 isoform is linked to higher cholesterol levels, an increased risk for cardiovascular issues, and a greater chance of developing Alzheimer's Disease, but its prevalence among US Latinos is unclear.
- Latino populations in the US have diverse genetic backgrounds due to their mixed Amerindian, European, and African ancestry, which varies by region.
- This report aims to analyze the distribution of the apoE4 isoform within a large sample of genetically diverse US Latinos to improve understanding of disease risk in this significant demographic.
Article Abstract
The apoE4 isoform is associated with increased cholesterol, cardiovascular risk, and Alzheimer's Disease risk, however, its distribution is not well-understood among US Latinos. Latinos living in the US are highly Amerindian, European and African admixed, which varies by region and country of origin. However, Latino genetic diversity is understudied and consequently poorly understood, which has significant implications for understanding disease risk in nearly one-fifth of the US population. In this report we describe apoE distributions in a large and representative sample of diverse, genetically determined US Latinos.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292877 | PMC |
| http://dx.doi.org/10.1038/s41598-018-35573-3 | DOI Listing |
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