AI Article Synopsis
- The development of the human nervous system is complex and requires careful timing and regulation of gene expression throughout various stages.
- Researchers collected transcriptomic data from different brain regions of developing rhesus macaques to compare with human data, revealing consistent patterns in gene expression changes during prenatal and postnatal stages.
- Their findings highlight differences in gene expression linked to neurodevelopmental disorders, offering insights into both human brain evolution and the causes of conditions like autism and schizophrenia.
Article Abstract
Human nervous system development is an intricate and protracted process that requires precise spatiotemporal transcriptional regulation. We generated tissue-level and single-cell transcriptomic data from up to 16 brain regions covering prenatal and postnatal rhesus macaque development. Integrative analysis with complementary human data revealed that global intraspecies (ontogenetic) and interspecies (phylogenetic) regional transcriptomic differences exhibit concerted cup-shaped patterns, with a late fetal-to-infancy (perinatal) convergence. Prenatal neocortical transcriptomic patterns revealed transient topographic gradients, whereas postnatal patterns largely reflected functional hierarchy. Genes exhibiting heterotopic and heterochronic divergence included those transiently enriched in the prenatal prefrontal cortex or linked to autism spectrum disorder and schizophrenia. Our findings shed light on transcriptomic programs underlying the evolution of human brain development and the pathogenesis of neuropsychiatric disorders.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900982 | PMC |
| http://dx.doi.org/10.1126/science.aat8077 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!